A0A062WP99 · A0A062WP99_STREE
- ProteinRibose-phosphate pyrophosphokinase
- GeneprsA_2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids322 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Catalytic activity
- D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H+
Cofactor
Note: Binds 2 Mg2+ ions per subunit.
Pathway
Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 39-41 | ATP (UniProtKB | ChEBI) | ||||
Sequence: DGE | ||||||
Binding site | 98-99 | ATP (UniProtKB | ChEBI) | ||||
Sequence: RQ | ||||||
Binding site | 132 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 173 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 196 | |||||
Sequence: K | ||||||
Binding site | 198 | D-ribose 5-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 224 | D-ribose 5-phosphate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 228-232 | D-ribose 5-phosphate (UniProtKB | ChEBI) | ||||
Sequence: DTAGT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | ribose phosphate diphosphokinase complex | |
Molecular Function | ATP binding | |
Molecular Function | kinase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | ribose phosphate diphosphokinase activity | |
Biological Process | 5-phosphoribose 1-diphosphate biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | ribonucleoside monophosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibose-phosphate pyrophosphokinase
- EC number
- Short namesRPPK
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionA0A062WP99
Proteomes
Subcellular Location
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-122 | Ribose-phosphate pyrophosphokinase N-terminal | ||||
Sequence: LKLFALSSNKELAERVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGKHVFILQSTSSPVNDNLLEILIMVDALKRASAESVNVVMPYYGYARQDRKARAREPITSKLVANMLEVAG |
Sequence similarities
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length322
- Mass (Da)35,451
- Last updated2014-09-03 v1
- Checksum11EE10055D7F1FE7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CFFA01000010 EMBL· GenBank· DDBJ | CEX63832.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CKCJ01000018 EMBL· GenBank· DDBJ | CIQ09879.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CKLF01000002 EMBL· GenBank· DDBJ | CIV06233.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CKRE01000039 EMBL· GenBank· DDBJ | CIY91044.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CMWB01000046 EMBL· GenBank· DDBJ | CKJ29752.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAVPGZ010000233 EMBL· GenBank· DDBJ | MDS8039752.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WNHJ01000009 EMBL· GenBank· DDBJ | MTV62534.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WNHQ01000320 EMBL· GenBank· DDBJ | MTV73306.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WNHN01000052 EMBL· GenBank· DDBJ | MTV77652.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WNHX01000059 EMBL· GenBank· DDBJ | MTV87733.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WNIB01000083 EMBL· GenBank· DDBJ | MTV90873.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WNIA01000083 EMBL· GenBank· DDBJ | MTV99443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WNHS01000045 EMBL· GenBank· DDBJ | MTW25082.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NNBW01000095 EMBL· GenBank· DDBJ | OYL27943.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHFW01000006 EMBL· GenBank· DDBJ | SUN83626.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VMWH01000037 EMBL· GenBank· DDBJ | TVW85456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VMYC01000037 EMBL· GenBank· DDBJ | TVX71667.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR216040 EMBL· GenBank· DDBJ | VFH93598.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR216055 EMBL· GenBank· DDBJ | VFI18742.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAANCB010000013 EMBL· GenBank· DDBJ | VKB77266.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAAQRO010000001 EMBL· GenBank· DDBJ | VMC81421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAASIK010000003 EMBL· GenBank· DDBJ | VNB44699.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAASRX010000018 EMBL· GenBank· DDBJ | VNH03980.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAAULE010000013 EMBL· GenBank· DDBJ | VOG82702.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAAXWD010000001 EMBL· GenBank· DDBJ | VQC96937.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CABABW010000010 EMBL· GenBank· DDBJ | VRI36564.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CABBMN010000012 EMBL· GenBank· DDBJ | VSC32851.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CABCSJ010000005 EMBL· GenBank· DDBJ | VST69703.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CABDLL010000004 EMBL· GenBank· DDBJ | VTE37301.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CABDQT010000016 EMBL· GenBank· DDBJ | VTH32013.1 EMBL· GenBank· DDBJ | Genomic DNA |