A0A062WP99 · A0A062WP99_STREE

  • Protein
    Ribose-phosphate pyrophosphokinase
  • Gene
    prsA_2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site39-41ATP (UniProtKB | ChEBI)
Binding site98-99ATP (UniProtKB | ChEBI)
Binding site132Mg2+ (UniProtKB | ChEBI)
Binding site173Mg2+ (UniProtKB | ChEBI)
Active site196
Binding site198D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site224D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site228-232D-ribose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribose phosphate diphosphokinase complex
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionribose phosphate diphosphokinase activity
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processphosphorylation
Biological Processpurine nucleotide biosynthetic process
Biological Processribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribose-phosphate pyrophosphokinase
  • EC number
  • Short names
    RPPK
  • Alternative names
    • 5-phospho-D-ribosyl alpha-1-diphosphate synthase
    • Phosphoribosyl diphosphate synthase
    • Phosphoribosyl pyrophosphate synthase
      (P-Rib-PP synthase
      ; PRPP synthase
      ; PRPPase
      )

Gene names

    • Name
      prsA_2
    • Synonyms
      prs
      , prsA_1
    • ORF names
      A5N45_07065
      , AZJ28_02455
      , AZJ70_04040
      , ERS019209_01074
      , ERS019261_01590
      , ERS019316_00289
      , ERS020485_01931
      , ERS096071_01911
      , GM535_10400
      , GM536_10305
      , GM537_09635
      , GM539_03725
      , GM540_04705
      , GM543_09530
      , GM544_10430
      , NCTC13734_00178
      , RLG82_12465
      , SAMEA2627268_00032
      , SAMEA2696453_01526
      , SAMEA2783718_00769
      , SAMEA3171064_01483
      , SAMEA3233211_00074
      , SAMEA3353485_01552
      , SAMEA3353631_01970
      , SAMEA3354366_00873
      , SAMEA3381439_00029
      , SAMEA3381574_01318
      , SAMEA3389245_01283
      , SAMEA3390019_01543
      , SAMEA4038883_00621

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 0310
    • 19F
    • SMRU103
    • SMRU158
    • SMRU51
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus

Accessions

  • Primary accession
    A0A062WP99

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-122Ribose-phosphate pyrophosphokinase N-terminal

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    322
  • Mass (Da)
    35,451
  • Last updated
    2014-09-03 v1
  • Checksum
    11EE10055D7F1FE7
MSFSDLKLFALSSNKELAERVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGKHVFILQSTSSPVNDNLLEILIMVDALKRASAESVNVVMPYYGYARQDRKARAREPITSKLVANMLEVAGVDRLLTIDLHAAQIQGFFDIPVDHLMGAPLIADYFERRGMVGSDYVVVSPDHGGVTRARKLAEFLKTSIAIIDKRRSVDKMNTSEVMNIIGKVEGKTCILIDDMIDTAGTICHAADALAEAGAVEVYASCTHPVLSGPATDNIQKSAIKKLVVLDTIYLPEERLIDKIEQISIAHLLGDAIVRIHEKRPLSPLFDIEKKI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CFFA01000010
EMBL· GenBank· DDBJ
CEX63832.1
EMBL· GenBank· DDBJ
Genomic DNA
CKCJ01000018
EMBL· GenBank· DDBJ
CIQ09879.1
EMBL· GenBank· DDBJ
Genomic DNA
CKLF01000002
EMBL· GenBank· DDBJ
CIV06233.1
EMBL· GenBank· DDBJ
Genomic DNA
CKRE01000039
EMBL· GenBank· DDBJ
CIY91044.1
EMBL· GenBank· DDBJ
Genomic DNA
CMWB01000046
EMBL· GenBank· DDBJ
CKJ29752.1
EMBL· GenBank· DDBJ
Genomic DNA
JAVPGZ010000233
EMBL· GenBank· DDBJ
MDS8039752.1
EMBL· GenBank· DDBJ
Genomic DNA
WNHJ01000009
EMBL· GenBank· DDBJ
MTV62534.1
EMBL· GenBank· DDBJ
Genomic DNA
WNHQ01000320
EMBL· GenBank· DDBJ
MTV73306.1
EMBL· GenBank· DDBJ
Genomic DNA
WNHN01000052
EMBL· GenBank· DDBJ
MTV77652.1
EMBL· GenBank· DDBJ
Genomic DNA
WNHX01000059
EMBL· GenBank· DDBJ
MTV87733.1
EMBL· GenBank· DDBJ
Genomic DNA
WNIB01000083
EMBL· GenBank· DDBJ
MTV90873.1
EMBL· GenBank· DDBJ
Genomic DNA
WNIA01000083
EMBL· GenBank· DDBJ
MTV99443.1
EMBL· GenBank· DDBJ
Genomic DNA
WNHS01000045
EMBL· GenBank· DDBJ
MTW25082.1
EMBL· GenBank· DDBJ
Genomic DNA
NNBW01000095
EMBL· GenBank· DDBJ
OYL27943.1
EMBL· GenBank· DDBJ
Genomic DNA
UHFW01000006
EMBL· GenBank· DDBJ
SUN83626.1
EMBL· GenBank· DDBJ
Genomic DNA
VMWH01000037
EMBL· GenBank· DDBJ
TVW85456.1
EMBL· GenBank· DDBJ
Genomic DNA
VMYC01000037
EMBL· GenBank· DDBJ
TVX71667.1
EMBL· GenBank· DDBJ
Genomic DNA
LR216040
EMBL· GenBank· DDBJ
VFH93598.1
EMBL· GenBank· DDBJ
Genomic DNA
LR216055
EMBL· GenBank· DDBJ
VFI18742.1
EMBL· GenBank· DDBJ
Genomic DNA
CAANCB010000013
EMBL· GenBank· DDBJ
VKB77266.1
EMBL· GenBank· DDBJ
Genomic DNA
CAAQRO010000001
EMBL· GenBank· DDBJ
VMC81421.1
EMBL· GenBank· DDBJ
Genomic DNA
CAASIK010000003
EMBL· GenBank· DDBJ
VNB44699.1
EMBL· GenBank· DDBJ
Genomic DNA
CAASRX010000018
EMBL· GenBank· DDBJ
VNH03980.1
EMBL· GenBank· DDBJ
Genomic DNA
CAAULE010000013
EMBL· GenBank· DDBJ
VOG82702.1
EMBL· GenBank· DDBJ
Genomic DNA
CAAXWD010000001
EMBL· GenBank· DDBJ
VQC96937.1
EMBL· GenBank· DDBJ
Genomic DNA
CABABW010000010
EMBL· GenBank· DDBJ
VRI36564.1
EMBL· GenBank· DDBJ
Genomic DNA
CABBMN010000012
EMBL· GenBank· DDBJ
VSC32851.1
EMBL· GenBank· DDBJ
Genomic DNA
CABCSJ010000005
EMBL· GenBank· DDBJ
VST69703.1
EMBL· GenBank· DDBJ
Genomic DNA
CABDLL010000004
EMBL· GenBank· DDBJ
VTE37301.1
EMBL· GenBank· DDBJ
Genomic DNA
CABDQT010000016
EMBL· GenBank· DDBJ
VTH32013.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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