A0A062WNW0 · A0A062WNW0_9ACTN
- ProteinDeoxyuridine 5'-triphosphate nucleotidohydrolase
- Genedut
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids196 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity
- dUTP + H2O = diphosphate + dUMP + H+
Cofactor
Pathway
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 97-99 | substrate | ||||
Sequence: RSG | ||||||
Binding site | 110 | substrate | ||||
Sequence: N | ||||||
Binding site | 114-116 | substrate | ||||
Sequence: TVD |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | dUMP biosynthetic process | |
Biological Process | dUTP catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxyuridine 5'-triphosphate nucleotidohydrolase
- EC number
- Short namesdUTPase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Frankiales > Frankiaceae > Frankia
Accessions
- Primary accessionA0A062WNW0
Proteomes
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-23 | Disordered | ||||
Sequence: MTATDPTTPTAPPTAPPPASAVP | ||||||
Compositional bias | 9-23 | Pro residues | ||||
Sequence: PTAPPTAPPPASAVP | ||||||
Domain | 47-177 | dUTPase-like | ||||
Sequence: LALPAYAQPSDAGADLVTAQDVTLGPGERATVGTGLSIALPAGYAAFVHPRSGLAARHGLSVVNAPGTVDAGYRGEIKVVLINTDRSDTIILHRGDRIAQLVVQRVEHAVFREVDELPASVRGSGGFGSTG | ||||||
Region | 177-196 | Disordered | ||||
Sequence: GGFGSAGGAGKETTGVRTRT |
Sequence similarities
Belongs to the dUTPase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length196
- Mass (Da)19,927
- Last updated2014-09-03 v1
- Checksum1D837C617CC4CE01
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 9-23 | Pro residues | ||||
Sequence: PTAPPTAPPPASAVP |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JDWE01000040 EMBL· GenBank· DDBJ | KDA41712.1 EMBL· GenBank· DDBJ | Genomic DNA |