A0A062V6K4 · A0A062V6K4_9PROT
- ProteinRibosomal RNA large subunit methyltransferase E
- GenerlmE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids234 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
Catalytic activity
- S-adenosyl-L-methionine + uridine2552 in 23S rRNA = 2'-O-methyluridine2552 in 23S rRNA + H+ + S-adenosyl-L-homocysteine
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 91 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 93 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 109 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 125 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 149 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 189 | Proton acceptor | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | rRNA (uridine-2'-O-)-methyltransferase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibosomal RNA large subunit methyltransferase E
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomonadales > Hyphomonadaceae > Hyphomonas
Accessions
- Primary accessionA0A062V6K4
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-37 | Disordered | ||||
Sequence: MSDDDRRRWKGPGPEKQDSGRRATERKVIARNARTES | ||||||
Domain | 59-232 | Ribosomal RNA methyltransferase FtsJ | ||||
Sequence: YRSRASYKLLEIDETAKLLRKGQRVVDLGCAPGGWIQVALQKGAVEVVGIDLLPLVPIEGALIIEGDVNNPEDVEKMLAGLSGPPDLVLSDMAANTTGHKQTDHLRTVALVEMAVAFAIEHLAEGGAFCAKVFQGGATKDVLDQLKQHFRTVKHIKPAASRAGSPEIYVVAKGF |
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length234
- Mass (Da)25,745
- Last updated2014-09-03 v1
- Checksum8BC215913FD4380D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ARYM01000016 EMBL· GenBank· DDBJ | KCZ97700.1 EMBL· GenBank· DDBJ | Genomic DNA |