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A0A061I2Z9 · A0A061I2Z9_CRIGR

Function

function

UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionglycosyltransferase activity
Molecular FunctionUDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
Biological Processdolichol-linked oligosaccharide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
  • EC number
  • Alternative names
    • GlcNAc-1-P transferase
    • N-acetylglucosamine-1-phosphate transferase

Gene names

    • ORF names
      H671_4g12996

Organism names

Accessions

  • Primary accession
    A0A061I2Z9

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane54-79Helical
Transmembrane91-110Helical
Transmembrane122-142Helical
Transmembrane163-185Helical
Transmembrane191-207Helical
Transmembrane219-240Helical
Transmembrane252-276Helical
Transmembrane375-397Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain314-356DPAGT1 insertion

Sequence similarities

Belongs to the glycosyltransferase 4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    404
  • Mass (Da)
    45,594
  • Last updated
    2014-09-03 v1
  • MD5 Checksum
    74E721B6563E9A0F070B3ED118B04E00
MSWSPGNHHPLPIPGSAASGLIPWLKLGPGHFIAARLCGQDLNKLSRQQIPESQGVICGAVFLIILFCFIPFPFLNCFVEEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRWILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDYRDDHVFSLYFMIPFFFTTLGLLYHNWYPSQVFVGDTFCYFAGMTFAVVGILGHFSKTMLLFFIPQVFNFLYSLPQLLHAIPCPRHRIPRLNPKTGKLEMSYSKFKTKNLSFLGTFILKVAERLQLVTVHRGESEDGAFTECNNMTLINLLLKIFGPIHERNLTLLLLLLQILSSAVTFSIRYQLVRLFYDV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KE675610
EMBL· GenBank· DDBJ
ERE75025.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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