A0A061CSK3 · A0A061CSK3_PSEOL

  • Protein
    Succinate--CoA ligase [ADP-forming] subunit alpha
  • Gene
    sucD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site17-20CoA (UniProtKB | ChEBI)
Binding site43CoA (UniProtKB | ChEBI)
Binding site96-98CoA (UniProtKB | ChEBI)
Binding site159substrate; ligand shared with subunit beta
Active site247Tele-phosphohistidine intermediate

GO annotations

AspectTerm
Molecular Functionnucleotide binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit alpha
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase subunit alpha
      (SCS-alpha
      )

Gene names

    • Name
      sucD
    • ORF names
      EGJ44_05125
      , N5J11_19165
      , N7581_20085
      , NCTC10692_03864
      , NCTC10860_02628

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • NCTC10692
    • NCTC10860
    • PO_271
    • GD03704
    • GD04039
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas > Pseudomonas oleovorans/pseudoalcaligenes group

Accessions

  • Primary accession
    A0A061CSK3
  • Secondary accessions
    • A0A379JXK1

Proteomes

Interaction

Subunit

Heterotetramer of two alpha and two beta subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-100CoA-binding

Sequence similarities

Belongs to the succinate/malate CoA ligase alpha subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    295
  • Mass (Da)
    30,187
  • Last updated
    2014-09-03 v1
  • Checksum
    BA997A2C51B15F07
MSVLINKDTKVICQGFTGSQGTFHSEQAIAYGTKMVGGVTPGKGGTTHLGLPVFNTVKEAVEATGADASVIYVPAPFCKDSILEAAFGGIKLIVCITEGIPTLDMLDAKVKCDELGVTLIGPNCPGVITPGECKIGIMPGHIHLPGKVGIVSRSGTLTYEAVKQTTDAGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPQTEAIVMIGEIGGSAEEEAAAYIKANVTKPVVSYIAGVTAPAGKRMGHAGAIISGGKGTADEKFAALQDAGVKTVRSLADIGKALAELTGWEVKKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAOEDG010000070
EMBL· GenBank· DDBJ
MDG9980290.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCJE010000001
EMBL· GenBank· DDBJ
MDH1341275.1
EMBL· GenBank· DDBJ
Genomic DNA
RHRS01000009
EMBL· GenBank· DDBJ
RRW38074.1
EMBL· GenBank· DDBJ
Genomic DNA
UGUV01000002
EMBL· GenBank· DDBJ
SUD53347.1
EMBL· GenBank· DDBJ
Genomic DNA
UGUW01000004
EMBL· GenBank· DDBJ
SUD60291.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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