A0A060WWU8 · A0A060WWU8_ONCMY

Function

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

152750100150200250300350400450500
TypeIDPosition(s)Description
Active site454Proton donor
Binding site458Zn2+ 1 (UniProtKB | ChEBI)
Binding site494Zn2+ 1 (UniProtKB | ChEBI)
Binding site495Zn2+ 2 (UniProtKB | ChEBI)
Binding site495Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
Molecular Functionmetal ion binding
Biological Processnegative regulation of cAMP-mediated signaling
Biological Processnegative regulation of cGMP-mediated signaling
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • ORF names
      GSONMT00008902001

Organism names

Accessions

  • Primary accession
    A0A060WWU8

Proteomes

PTM/Processing

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain378-527PDEase

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    527
  • Mass (Da)
    59,480
  • Last updated
    2014-09-03 v1
  • Checksum
    446A1EA3E41B5100
MAVSNMVFSDVESFLDTHPELFEDYLNRKGKHTSSLPPTTAHILSALLESRVNIPQYPSTAVDFKYYLKEHNEREFFLELVKDISNDLDLTSLSYKILVFVCIMVDADRCSLFLVEGSANKKTLVSKFFDVHAGITVLPSMSNSDEVQVPWGKGIIGYVAEHGETVNIPDAYQDRRFSDEIDKLSGYKTKSLLCMPIHNSDGEIIGVAQAINKSPGGALFTEDDEKRLYVQPIDCLPDVMSSQVLQMYLPFCGIAISNAQLFAASRKEYDRSRSLLEVVNDLFEEQTDLEKIVRKIMYRAQTLLKCERCSVQLLEDIESPVVKFTKSFELLSPKCSADIESSFKDSMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEAANIPLVCELGIDKLSFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQCMFAILTTAGFQETLTEIEILALIVGCVCHDLDHRGTNNAFQAKWVTLSVDTRTLAGTHAQAL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FR904793
EMBL· GenBank· DDBJ
CDQ71823.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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