A0A060W743 · A0A060W743_ONCMY
- ProteinMannose-6-phosphate isomerase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids441 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Isomerase that catalyzes the interconversion of fructose-6-P and mannose-6-P and has a critical role in the supply of D-mannose derivatives required for many eukaryotic glycosylation reactions.
Catalytic activity
- D-mannose 6-phosphate = D-fructose 6-phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | mannose-6-phosphate isomerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | GDP-mannose biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMannose-6-phosphate isomerase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Salmoninae > Oncorhynchus
Accessions
- Primary accessionA0A060W743
Proteomes
PTM/Processing
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 25-173 | Phosphomannose isomerase type I catalytic | ||||
Sequence: VFPLSCAVQNYAWGKVGLDSEVAKLVVGGDTSAVIEADKHYAELWMGAHPKGDALIKDNRIAQRTLGQWIADYPACLGSKVKDTFQGQLPFLFKVLSVNTALSIQAHPNRELAGRLHAQFPEHYPDNNHKPEMAVALTHFEGLCGFRPV | ||||||
Domain | 189-275 | Phosphomannose isomerase type I helical insertion | ||||
Sequence: LVGSETAEELVSSRGEAGRTSLALKKCFTRMMNCEKKVFVDQLNMLVKRVTEEAAAGKDTSDSNSELLLRLHSQYPGDIGCFSIYFL | ||||||
Domain | 355-396 | Phosphomannose isomerase type I C-terminal | ||||
Sequence: LYDPPVPDFTVMRIQVPDSVRQYTVAPVDCAGILLVIEGEAT |
Sequence similarities
Belongs to the mannose-6-phosphate isomerase type 1 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length441
- Mass (Da)48,235
- Last updated2014-09-03 v1
- ChecksumD2657BE51E82CD83
Keywords
- Technical term