A0A060W743 · A0A060W743_ONCMY

Function

function

Isomerase that catalyzes the interconversion of fructose-6-P and mannose-6-P and has a critical role in the supply of D-mannose derivatives required for many eukaryotic glycosylation reactions.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site129Zn2+ (UniProtKB | ChEBI)
Binding site131Zn2+ (UniProtKB | ChEBI)
Binding site156Zn2+ (UniProtKB | ChEBI)
Binding site294Zn2+ (UniProtKB | ChEBI)
Active site313

GO annotations

AspectTerm
Molecular Functionmannose-6-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological Processcarbohydrate metabolic process
Biological ProcessGDP-mannose biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mannose-6-phosphate isomerase
  • EC number

Gene names

    • ORF names
      GSONMT00081683001

Organism names

Accessions

  • Primary accession
    A0A060W743

Proteomes

PTM/Processing

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain25-173Phosphomannose isomerase type I catalytic
Domain189-275Phosphomannose isomerase type I helical insertion
Domain355-396Phosphomannose isomerase type I C-terminal

Sequence similarities

Belongs to the mannose-6-phosphate isomerase type 1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    441
  • Mass (Da)
    48,235
  • Last updated
    2014-09-03 v1
  • Checksum
    D2657BE51E82CD83
MSPWPYKDVRTTVIADVAAMEEVRVFPLSCAVQNYAWGKVGLDSEVAKLVVGGDTSAVIEADKHYAELWMGAHPKGDALIKDNRIAQRTLGQWIADYPACLGSKVKDTFQGQLPFLFKVLSVNTALSIQAHPNRELAGRLHAQFPEHYPDNNHKPEMAVALTHFEGLCGFRPVEEIIGFLKSVPEFHTLVGSETAEELVSSRGEAGRTSLALKKCFTRMMNCEKKVFVDQLNMLVKRVTEEAAAGKDTSDSNSELLLRLHSQYPGDIGCFSIYFLNRIVLEPGDAMFLGANEPHAYLNGDCIECMACSDNTVRAGLTPKFIDVNTLCEMLNYSPAPASAKIFPSIQDPSDPFVYLYDPPVPDFTVMRIQVPDSVRQYTVAPVDCAGILLVIEGEATGTTAAALSDITLSRGTVLFISANESVSLHITSPSGMTMYRACSLL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FR904347
EMBL· GenBank· DDBJ
CDQ60375.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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