A0A060VEM3 · A0A060VEM3_KLEPN
- ProteinTyrosine recombinase XerD
- GenexerD_1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids298 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerD specifically exchanges the bottom DNA strands.
Activity regulation
FtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 148 | |||||
Sequence: R | ||||||
Active site | 172 | |||||
Sequence: K | ||||||
Active site | 244 | |||||
Sequence: H | ||||||
Active site | 247 | |||||
Sequence: R | ||||||
Active site | 270 | |||||
Sequence: H | ||||||
Active site | 279 | O-(3'-phospho-DNA)-tyrosine intermediate | ||||
Sequence: Y |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | DNA binding | |
Molecular Function | tyrosine-based site-specific recombinase activity | |
Biological Process | cell division | |
Biological Process | chromosome segregation | |
Biological Process | DNA transposition |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTyrosine recombinase XerD
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA0A060VEM3
- Secondary accessions
Proteomes
Subcellular Location
Interaction
Subunit
Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-87 | Core-binding (CB) | ||||
Sequence: KQDLALIEQFLDALWLERNLAENTLSAYRRDLTMLVEWLHHRGLSLASVGSDDLQALLAERQSGGYKATSTARLLSAVRRFFQHLY | ||||||
Domain | 108-292 | Tyr recombinase | ||||
Sequence: RLPKDLSEAQVERLLQAPLVEQPLELRDKAMLEVLYATGLRVSELVGLTMSDISLRQGVLRVVGKGNKERLVPLGEEAVLWVENYLEYGRPWLLNGVASDVLFPSQRAQQMTRQTFWHRIKHYAVLAGIDSEKLSPHVLRHAFATHLLNHGADLRVVQMLLGHSDLSTTQIYTHVATERLRQLHQ |
Sequence similarities
Belongs to the 'phage' integrase family. XerD subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length298
- Mass (Da)33,967
- Last updated2014-09-03 v1
- ChecksumDF893A2E8C2D2B88
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JRRF01000004 EMBL· GenBank· DDBJ | KII07241.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LNHP01000054 EMBL· GenBank· DDBJ | KSX87577.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAECTB010000001 EMBL· GenBank· DDBJ | MBH8348811.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAUUIA010000028 EMBL· GenBank· DDBJ | MDP0970194.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WJVL01000023 EMBL· GenBank· DDBJ | MRJ98980.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WJWF01000039 EMBL· GenBank· DDBJ | MRL38647.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VINI01000024 EMBL· GenBank· DDBJ | MSS33672.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WNPO01000045 EMBL· GenBank· DDBJ | MUA42959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAKYD010000028 EMBL· GenBank· DDBJ | NGN75204.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NDBK01000064 EMBL· GenBank· DDBJ | OVF70901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MSYX01000010 EMBL· GenBank· DDBJ | OWA82504.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NCMJ01000054 EMBL· GenBank· DDBJ | PLE27793.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PCFF01000001 EMBL· GenBank· DDBJ | PVU64335.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP055517 EMBL· GenBank· DDBJ | QLO17737.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP063008 EMBL· GenBank· DDBJ | QOU52670.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP066534 EMBL· GenBank· DDBJ | QQL33013.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP068602 EMBL· GenBank· DDBJ | QQZ72456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QOUB01000001 EMBL· GenBank· DDBJ | RCJ54523.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QRCD01000011 EMBL· GenBank· DDBJ | RDT88972.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MPYG04000255 EMBL· GenBank· DDBJ | ROG84450.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RDAM01000001 EMBL· GenBank· DDBJ | RRF06376.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SGOL01000007 EMBL· GenBank· DDBJ | RZG38655.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FLDK01000005 EMBL· GenBank· DDBJ | SBH13745.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UASO01000004 EMBL· GenBank· DDBJ | SQC22324.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UAWQ01000018 EMBL· GenBank· DDBJ | SQC45359.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFEU01000002 EMBL· GenBank· DDBJ | SSK22593.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGKT01000001 EMBL· GenBank· DDBJ | STT06328.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGLC01000002 EMBL· GenBank· DDBJ | STT56586.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGLH01000006 EMBL· GenBank· DDBJ | STT81935.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGLJ01000002 EMBL· GenBank· DDBJ | STT95675.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGLQ01000003 EMBL· GenBank· DDBJ | STU29063.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGMD01000002 EMBL· GenBank· DDBJ | STV03030.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGMG01000001 EMBL· GenBank· DDBJ | STV33488.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGMN01000004 EMBL· GenBank· DDBJ | STV51837.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UIUC01000001 EMBL· GenBank· DDBJ | SVN62221.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UJHH01000010 EMBL· GenBank· DDBJ | SWF72294.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UJRG01000003 EMBL· GenBank· DDBJ | SWT11023.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKAW01000002 EMBL· GenBank· DDBJ | SXG11045.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKGE01000006 EMBL· GenBank· DDBJ | SXN30647.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKRD01000008 EMBL· GenBank· DDBJ | SYC20720.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKUT01000004 EMBL· GenBank· DDBJ | SYH31270.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ULCI01000006 EMBL· GenBank· DDBJ | SYR35506.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ULET01000019 EMBL· GenBank· DDBJ | SYU76819.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VSSY01000003 EMBL· GenBank· DDBJ | TYL81586.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWVH01000001 EMBL· GenBank· DDBJ | VCV76643.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWWS01000001 EMBL· GenBank· DDBJ | VCX96258.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR134162 EMBL· GenBank· DDBJ | VEB02248.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAAHAW010000002 EMBL· GenBank· DDBJ | VGJ15405.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAAHCC010000014 EMBL· GenBank· DDBJ | VGL14206.1 EMBL· GenBank· DDBJ | Genomic DNA |