A0A060VEM3 · A0A060VEM3_KLEPN

  • Protein
    Tyrosine recombinase XerD
  • Gene
    xerD_1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerD specifically exchanges the bottom DNA strands.

Activity regulation

FtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.

Features

Showing features for active site.

129820406080100120140160180200220240260280
TypeIDPosition(s)Description
Active site148
Active site172
Active site244
Active site247
Active site270
Active site279O-(3'-phospho-DNA)-tyrosine intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular FunctionDNA binding
Molecular Functiontyrosine-based site-specific recombinase activity
Biological Processcell division
Biological Processchromosome segregation
Biological ProcessDNA transposition

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine recombinase XerD

Gene names

    • Name
      xerD_1
    • Synonyms
      xerD
      , xerD_2
      , xerD_3
      , xerD_4
    • ORF names
      APT92_25765
      , B5L96_14520
      , B6I68_10345
      , BANRA_00859
      , BANRA_02604
      , BL124_00033500
      , BV369_09080
      , CP554_00065
      , DM083_01890
      , DW281_12810
      , EAO17_09240
      , EXT45_09365
      , FME62_23165
      , FXN67_05480
      , G4V31_24215
      , GJJ01_23895
      , GJJ08_004405
      , GJJ18_24915
      , GNF00_24250
      , H3G96_023290
      , HV185_04130
      , I8R04_02190
      , JMZ77_04425
      , LS45_08105
      , NCTC11679_00882
      , NCTC13443_06275
      , NCTC13465_03909
      , NCTC13635_02708
      , NCTC204_03084
      , NCTC5047_02873
      , NCTC5052_04183
      , NCTC5053_05258
      , NCTC8849_05245
      , NCTC9645_02901
      , NCTC9661_01619
      , Q6294_24575
      , SAMEA2273558_02194
      , SAMEA3499874_00840
      , SAMEA3499901_01654
      , SAMEA3515122_02164
      , SAMEA3538551_03684
      , SAMEA3538828_01629
      , SAMEA3649591_00289
      , SAMEA3649615_04738
      , SAMEA3720909_02519
      , SAMEA3729652_01762
      , SAMEA4364603_00912
      , SAMEA4873597_01096
      , SAMEA4873632_04892

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 53
    • 2429
    • 39383
    • 59493
    • 50627996
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    A0A060VEM3
  • Secondary accessions
    • A0A0J2FNU8
    • A0A4V0H0I6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-87Core-binding (CB)
Domain108-292Tyr recombinase

Sequence similarities

Belongs to the 'phage' integrase family. XerD subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    298
  • Mass (Da)
    33,967
  • Last updated
    2014-09-03 v1
  • Checksum
    DF893A2E8C2D2B88
MKQDLALIEQFLDALWLERNLAENTLSAYRRDLTMLVEWLHHRGLSLASVGSDDLQALLAERQSGGYKATSTARLLSAVRRFFQHLYREKIRPDDPSALLASPKLPQRLPKDLSEAQVERLLQAPLVEQPLELRDKAMLEVLYATGLRVSELVGLTMSDISLRQGVLRVVGKGNKERLVPLGEEAVLWVENYLEYGRPWLLNGVASDVLFPSQRAQQMTRQTFWHRIKHYAVLAGIDSEKLSPHVLRHAFATHLLNHGADLRVVQMLLGHSDLSTTQIYTHVATERLRQLHQQHHPRA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JRRF01000004
EMBL· GenBank· DDBJ
KII07241.1
EMBL· GenBank· DDBJ
Genomic DNA
LNHP01000054
EMBL· GenBank· DDBJ
KSX87577.1
EMBL· GenBank· DDBJ
Genomic DNA
JAECTB010000001
EMBL· GenBank· DDBJ
MBH8348811.1
EMBL· GenBank· DDBJ
Genomic DNA
JAUUIA010000028
EMBL· GenBank· DDBJ
MDP0970194.1
EMBL· GenBank· DDBJ
Genomic DNA
WJVL01000023
EMBL· GenBank· DDBJ
MRJ98980.1
EMBL· GenBank· DDBJ
Genomic DNA
WJWF01000039
EMBL· GenBank· DDBJ
MRL38647.1
EMBL· GenBank· DDBJ
Genomic DNA
VINI01000024
EMBL· GenBank· DDBJ
MSS33672.1
EMBL· GenBank· DDBJ
Genomic DNA
WNPO01000045
EMBL· GenBank· DDBJ
MUA42959.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAKYD010000028
EMBL· GenBank· DDBJ
NGN75204.1
EMBL· GenBank· DDBJ
Genomic DNA
NDBK01000064
EMBL· GenBank· DDBJ
OVF70901.1
EMBL· GenBank· DDBJ
Genomic DNA
MSYX01000010
EMBL· GenBank· DDBJ
OWA82504.1
EMBL· GenBank· DDBJ
Genomic DNA
NCMJ01000054
EMBL· GenBank· DDBJ
PLE27793.1
EMBL· GenBank· DDBJ
Genomic DNA
PCFF01000001
EMBL· GenBank· DDBJ
PVU64335.1
EMBL· GenBank· DDBJ
Genomic DNA
CP055517
EMBL· GenBank· DDBJ
QLO17737.1
EMBL· GenBank· DDBJ
Genomic DNA
CP063008
EMBL· GenBank· DDBJ
QOU52670.1
EMBL· GenBank· DDBJ
Genomic DNA
CP066534
EMBL· GenBank· DDBJ
QQL33013.1
EMBL· GenBank· DDBJ
Genomic DNA
CP068602
EMBL· GenBank· DDBJ
QQZ72456.1
EMBL· GenBank· DDBJ
Genomic DNA
QOUB01000001
EMBL· GenBank· DDBJ
RCJ54523.1
EMBL· GenBank· DDBJ
Genomic DNA
QRCD01000011
EMBL· GenBank· DDBJ
RDT88972.1
EMBL· GenBank· DDBJ
Genomic DNA
MPYG04000255
EMBL· GenBank· DDBJ
ROG84450.1
EMBL· GenBank· DDBJ
Genomic DNA
RDAM01000001
EMBL· GenBank· DDBJ
RRF06376.1
EMBL· GenBank· DDBJ
Genomic DNA
SGOL01000007
EMBL· GenBank· DDBJ
RZG38655.1
EMBL· GenBank· DDBJ
Genomic DNA
FLDK01000005
EMBL· GenBank· DDBJ
SBH13745.1
EMBL· GenBank· DDBJ
Genomic DNA
UASO01000004
EMBL· GenBank· DDBJ
SQC22324.1
EMBL· GenBank· DDBJ
Genomic DNA
UAWQ01000018
EMBL· GenBank· DDBJ
SQC45359.1
EMBL· GenBank· DDBJ
Genomic DNA
UFEU01000002
EMBL· GenBank· DDBJ
SSK22593.1
EMBL· GenBank· DDBJ
Genomic DNA
UGKT01000001
EMBL· GenBank· DDBJ
STT06328.1
EMBL· GenBank· DDBJ
Genomic DNA
UGLC01000002
EMBL· GenBank· DDBJ
STT56586.1
EMBL· GenBank· DDBJ
Genomic DNA
UGLH01000006
EMBL· GenBank· DDBJ
STT81935.1
EMBL· GenBank· DDBJ
Genomic DNA
UGLJ01000002
EMBL· GenBank· DDBJ
STT95675.1
EMBL· GenBank· DDBJ
Genomic DNA
UGLQ01000003
EMBL· GenBank· DDBJ
STU29063.1
EMBL· GenBank· DDBJ
Genomic DNA
UGMD01000002
EMBL· GenBank· DDBJ
STV03030.1
EMBL· GenBank· DDBJ
Genomic DNA
UGMG01000001
EMBL· GenBank· DDBJ
STV33488.1
EMBL· GenBank· DDBJ
Genomic DNA
UGMN01000004
EMBL· GenBank· DDBJ
STV51837.1
EMBL· GenBank· DDBJ
Genomic DNA
UIUC01000001
EMBL· GenBank· DDBJ
SVN62221.1
EMBL· GenBank· DDBJ
Genomic DNA
UJHH01000010
EMBL· GenBank· DDBJ
SWF72294.1
EMBL· GenBank· DDBJ
Genomic DNA
UJRG01000003
EMBL· GenBank· DDBJ
SWT11023.1
EMBL· GenBank· DDBJ
Genomic DNA
UKAW01000002
EMBL· GenBank· DDBJ
SXG11045.1
EMBL· GenBank· DDBJ
Genomic DNA
UKGE01000006
EMBL· GenBank· DDBJ
SXN30647.1
EMBL· GenBank· DDBJ
Genomic DNA
UKRD01000008
EMBL· GenBank· DDBJ
SYC20720.1
EMBL· GenBank· DDBJ
Genomic DNA
UKUT01000004
EMBL· GenBank· DDBJ
SYH31270.1
EMBL· GenBank· DDBJ
Genomic DNA
ULCI01000006
EMBL· GenBank· DDBJ
SYR35506.1
EMBL· GenBank· DDBJ
Genomic DNA
ULET01000019
EMBL· GenBank· DDBJ
SYU76819.1
EMBL· GenBank· DDBJ
Genomic DNA
VSSY01000003
EMBL· GenBank· DDBJ
TYL81586.1
EMBL· GenBank· DDBJ
Genomic DNA
UWVH01000001
EMBL· GenBank· DDBJ
VCV76643.1
EMBL· GenBank· DDBJ
Genomic DNA
UWWS01000001
EMBL· GenBank· DDBJ
VCX96258.1
EMBL· GenBank· DDBJ
Genomic DNA
LR134162
EMBL· GenBank· DDBJ
VEB02248.1
EMBL· GenBank· DDBJ
Genomic DNA
CAAHAW010000002
EMBL· GenBank· DDBJ
VGJ15405.1
EMBL· GenBank· DDBJ
Genomic DNA
CAAHCC010000014
EMBL· GenBank· DDBJ
VGL14206.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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