A0A060PYA7 · A0A060PYA7_9ALPH

  • Protein
    Ribonucleoside-diphosphate reductase large subunit
  • Gene
    UL39
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activity

Features

Showing features for binding site, site, active site.

112431002003004005006007008009001,0001,1001,200
TypeIDPosition(s)Description
Binding site672substrate
Binding site687-688substrate
Site688Important for hydrogen atom transfer
Binding site718substrate
Active site897Proton acceptor
Binding site897-901substrate
Active site899Cysteine radical intermediate
Active site901Proton acceptor
Site914Important for hydrogen atom transfer
Binding site1074-1078substrate
Site1217Important for electron transfer
Site1218Important for electron transfer
Site1238Interacts with thioredoxin/glutaredoxin
Site1241Interacts with thioredoxin/glutaredoxin

GO annotations

AspectTerm
Cellular Componentribonucleoside-diphosphate reductase complex
Molecular FunctionATP binding
Molecular Functionribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Processdeoxyribonucleotide biosynthetic process
Biological ProcessDNA replication
Biological Processviral process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonucleoside-diphosphate reductase large subunit
  • EC number
  • Short names
    R1
  • Alternative names
    • Ribonucleotide reductase large subunit

Gene names

    • Name
      UL39
    • Synonyms
      RIR1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Viruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Simplexvirus > Simplexvirus pteropodidalpha1

Accessions

  • Primary accession
    A0A060PYA7

Proteomes

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond688↔914Redox-active

Keywords

Expression

Keywords

Interaction

Subunit

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-34Disordered
Region134-384Disordered
Compositional bias143-160Pro residues
Compositional bias161-186Polar residues
Compositional bias279-304Polar residues
Compositional bias331-349Polar residues
Compositional bias351-368Pro residues
Domain1052-1074Ribonucleotide reductase large subunit

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,243
  • Mass (Da)
    137,219
  • Last updated
    2014-09-03 v1
  • Checksum
    E68D68AC350BE06C
MASFPNASNNQRSARTFKRPRRMEPSAAGAGPSNPASGSGYFFFCDRASNVTVVPPVVPDGMACHISNSHFIQCGSNCMMIVDGSASCPPVVYRPTPPVAQPFPPSSVTVTSRQHGENSRTTAVVFTEHASGAGAISSAAPPSPPKLTKPANPPASPTPAYPSTTSLSSTTASSWTPLYSRPRSGDSESSTESEWEDEDADTRPRGGADSEFYLDFSTKKWQPEPNQGKDAASHPNPEAPMESAIKSESESEANTDSDSDSNSESESDAGATGETALAAGPTPTANPTSGCESESETETESLCDATLLSEDEFGSDEDFLVALPHPPDAGQCCSLSTSGPTSADDRQSSGNPPPAKPPRCPESPLAQPPTCPEAAAAHSDAACQTTNPALDEEEARYEAVDIVIPSTPVLDALDIQFGMPRRLKFPVPPDPTHENVTAVVKFLKLRRKYEPLVFLEYFYQCAHRVEETAGPQSFARQPFLSRSEFGLLRYALSELQGLFMDVPQIPVNIHRPFAFSNYITTLVNKFKPLVRRSEKLYQILGLLVHLRIRTRAASFREWMQSPDVKLDAELVKQLHTHERRLLDFFEGLEYGPARRFMERGLQSALKYEEFYLRPFGGYSLESVNQMYTRIAGFLACHATDCQQLIFGRPATWFELFLYFFQYLYDHKIVPSTPAMLNLGRRNYYTSSCYLVNPQTTTNKATLDALTHNVKDILAQRGGVGLCLQSFNDAHRKQASLMPALKVLDSLVAAYNHASRRPTGVCVYIEPWHSDIMSILRMKGVLAGEEAQRCDNLFSALWMPDLFFKRLIRHLEGETGVLWTLFDKAESMALSDFHGQEFENLYEVYEQMGLGNPMPIQDVAFAIVRSAATTGSPFIMFKDAVNRHYIYDTQGAAISGSNLCTEIVHPADKDSSGVCNLGSVNLAACVVDGVFSFDQLRQAVQACVLMVNVMIDCASQPTIQCRRGHDRFRSMGIGMQGLHTAALMLGLDMTSEAFRELNKHIAEVMLLAAMKTSNGLCRHGAEPFAEFGKSMYRAGRFHWERFPDAKPRYEGEWDLLRQSMMRFGLRNSQFIALMPTVTSSQVSEVSEGFAPLFTNMFSKVTKEGELLRPNILLLRELRKTFGGKRLLDVLDKLDSTQWSVEKALPCLAPNHPLRKFKTAFDYDQTLLIDLCADRAPYVDHSQSMTLYVSESANGTLPASTLTRLLIHAYKRGLKTGMYYCKVRKATNSGVFGGDENLVCTSCVL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias143-160Pro residues
Compositional bias161-186Polar residues
Compositional bias279-304Polar residues
Compositional bias331-349Polar residues
Compositional bias351-368Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB825953
EMBL· GenBank· DDBJ
BAP00718.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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