A0A060IPE9 · A0A060IPE9_9REOV

  • Protein
    Non-structural protein 1
  • Gene
    NSP1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Organism
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities. Recognizes the host NF-kappa-B regulator BTRC through the presence of a DSGXS motif in the C-terminal substrate recognition domain.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cytoskeleton
Molecular Functionmetal ion binding
Molecular FunctionRNA binding
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
Biological Processsymbiont-mediated suppression of host NF-kappaB cascade
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Non-structural protein 1
  • Short names
    NSP1
  • Alternative names
    • NCVP2
    • Non-structural RNA-binding protein 53
      (NS53
      )

Gene names

    • Name
      NSP1

Organism names

  • Taxonomic identifier
  • Organism
    Rotavirus A
  • Strain
    • RVA/Pig-tc/ESP/OSU-C5111/2010/G5P[7]
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Duplornaviricota > Resentoviricetes > Reovirales > Sedoreoviridae > Rotavirus

Accessions

  • Primary accession
    A0A060IPE9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Post-translational modification

The C-terminal region is phosphorylated by host CKII/CSNK2A1. Phosphorylation of the DSGXS motif is essential for host NF-kappa-B inhibition.

Keywords

Interaction

Subunit

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation. Interacts with host CUL1 and CUL3. Interacts with host BTRC.

Family & Domains

Features

Showing features for region, motif.

TypeIDPosition(s)Description
Region8-88RNA-binding
Region49-86Zinc-binding domain
Region324-493Interaction with host IRF3
Motif486-490IKBKB-like degron (ILD) motif

Domain

The integrity of the zinc-binding domain in NSP1 is important for degradation of host IRF3.

Sequence similarities

Belongs to the rotavirus NSP1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    493
  • Mass (Da)
    57,963
  • Last updated
    2014-09-03 v1
  • Checksum
    CB4C4A37A39AC414
MKGLVEAMATFKDACYYYKRINKLNHAVLKLGVNDTWRPSPPTKYKGWCLDCCQHTDLTYCRGCTMYHVCQWCSQYGRCFLDNEPHLLRMRTFKNEVTKDDLMNLVDMYDTLFPMNQKIVDKFINNTRQHKCRNECVNQWYNHLLMPITLQSLSIELDGDVYYIFGYYDDMNNVNQTPFSFVNLVDIYDKLLLDDVNFTRMSFLPVTLQQEYALRYFSKSRFISEQRKCVSDSHFSINVLENLHNPSFKMQITRNCSELSSDWNGACKLVKDTSAYFNILKTSHVEFYSISTRCRVFTQRKLKIASKLIKPNYITSNHRTSATEVHNCKWCSINSSYTVWNDFRVKKIYDNIFNFLRALVKSNVNVGHCSSQEKIYECVENILDVCDNEKWKTSVTKIFNYLEPVELNAVNYVLFNHEVNWDVINVLVQSIGKVPQILTLNDVTTIMQSIIYEWFDTKYMRNTPMTTFTVDKLRRLCTGSKTVDYDSGISDVE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ450846
EMBL· GenBank· DDBJ
AIC34771.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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