A0A060A558 · A0A060A558_ZEUCU
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids263 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Tephritoidea > Tephritidae > Zeugodacus > Zeugodacus
Accessions
- Primary accessionA0A060A558
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 21-41 | Helical | ||||
Sequence: LGMIYAMMAIGLLGFIVWAHH | ||||||
Transmembrane | 53-75 | Helical | ||||
Sequence: AYFTSATMIIAVPTGIKIFSWLA | ||||||
Transmembrane | 87-109 | Helical | ||||
Sequence: AMLWALGFVFLFTVGGLTGVVLA | ||||||
Transmembrane | 129-150 | Helical | ||||
Sequence: YVLSMGAVFAIMAGFVHWYPLF | ||||||
Transmembrane | 162-180 | Helical | ||||
Sequence: SQFIIMFIGVNLTFFPQHF | ||||||
Transmembrane | 200-223 | Helical | ||||
Sequence: WNVVSTIGSSISLLGILFFLFIIW |
Keywords
- Cellular component
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-262 | Cytochrome oxidase subunit I profile | ||||
Sequence: FGMISHIISQESGKKETFGSLGMIYAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQLNYSPAMLWALGFVFLFTVGGLTGVVLANSSVDIILHDTYYVVAHFHYVLSMGAVFAIMAGFVHWYPLFTGLVLNPKWLKSQFIIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTTWNVVSTIGSSISLLGILFFLFIIWESLVTQRQVIYPMQLSSSIEWLQNTPPAEHSYSELPLLT |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length263
- Mass (Da)29,480
- Last updated2014-09-03 v1
- ChecksumDCF93204D11B500D
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: F |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KJ142766 EMBL· GenBank· DDBJ | AIA59754.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142767 EMBL· GenBank· DDBJ | AIA59755.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142768 EMBL· GenBank· DDBJ | AIA59756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142769 EMBL· GenBank· DDBJ | AIA59757.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142770 EMBL· GenBank· DDBJ | AIA59758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142771 EMBL· GenBank· DDBJ | AIA59759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142772 EMBL· GenBank· DDBJ | AIA59760.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142773 EMBL· GenBank· DDBJ | AIA59761.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142774 EMBL· GenBank· DDBJ | AIA59762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142775 EMBL· GenBank· DDBJ | AIA59763.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142776 EMBL· GenBank· DDBJ | AIA59764.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142777 EMBL· GenBank· DDBJ | AIA59765.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142778 EMBL· GenBank· DDBJ | AIA59766.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142779 EMBL· GenBank· DDBJ | AIA59767.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142780 EMBL· GenBank· DDBJ | AIA59768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142782 EMBL· GenBank· DDBJ | AIA59770.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142783 EMBL· GenBank· DDBJ | AIA59771.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142784 EMBL· GenBank· DDBJ | AIA59772.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142785 EMBL· GenBank· DDBJ | AIA59773.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142786 EMBL· GenBank· DDBJ | AIA59774.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142787 EMBL· GenBank· DDBJ | AIA59775.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142788 EMBL· GenBank· DDBJ | AIA59776.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142789 EMBL· GenBank· DDBJ | AIA59777.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142790 EMBL· GenBank· DDBJ | AIA59778.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142792 EMBL· GenBank· DDBJ | AIA59780.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142793 EMBL· GenBank· DDBJ | AIA59781.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142794 EMBL· GenBank· DDBJ | AIA59782.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142795 EMBL· GenBank· DDBJ | AIA59783.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142796 EMBL· GenBank· DDBJ | AIA59784.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142797 EMBL· GenBank· DDBJ | AIA59785.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142798 EMBL· GenBank· DDBJ | AIA59786.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142799 EMBL· GenBank· DDBJ | AIA59787.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142800 EMBL· GenBank· DDBJ | AIA59788.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142801 EMBL· GenBank· DDBJ | AIA59789.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ142802 EMBL· GenBank· DDBJ | AIA59790.1 EMBL· GenBank· DDBJ | Genomic DNA |