A0A060A558 · A0A060A558_ZEUCU

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A060A558

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-41Helical
Transmembrane53-75Helical
Transmembrane87-109Helical
Transmembrane129-150Helical
Transmembrane162-180Helical
Transmembrane200-223Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-262Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    263
  • Mass (Da)
    29,480
  • Last updated
    2014-09-03 v1
  • Checksum
    DCF93204D11B500D
FGMISHIISQESGKKETFGSLGMIYAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQLNYSPAMLWALGFVFLFTVGGLTGVVLANSSVDIILHDTYYVVAHFHYVLSMGAVFAIMAGFVHWYPLFTGLVLNPKWLKSQFIIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTTWNVVSTIGSSISLLGILFFLFIIWESLVTQRQVIYPMQLSSSIEWLQNTPPAEHSYSELPLLTN

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ142766
EMBL· GenBank· DDBJ
AIA59754.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142767
EMBL· GenBank· DDBJ
AIA59755.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142768
EMBL· GenBank· DDBJ
AIA59756.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142769
EMBL· GenBank· DDBJ
AIA59757.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142770
EMBL· GenBank· DDBJ
AIA59758.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142771
EMBL· GenBank· DDBJ
AIA59759.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142772
EMBL· GenBank· DDBJ
AIA59760.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142773
EMBL· GenBank· DDBJ
AIA59761.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142774
EMBL· GenBank· DDBJ
AIA59762.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142775
EMBL· GenBank· DDBJ
AIA59763.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142776
EMBL· GenBank· DDBJ
AIA59764.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142777
EMBL· GenBank· DDBJ
AIA59765.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142778
EMBL· GenBank· DDBJ
AIA59766.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142779
EMBL· GenBank· DDBJ
AIA59767.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142780
EMBL· GenBank· DDBJ
AIA59768.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142782
EMBL· GenBank· DDBJ
AIA59770.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142783
EMBL· GenBank· DDBJ
AIA59771.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142784
EMBL· GenBank· DDBJ
AIA59772.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142785
EMBL· GenBank· DDBJ
AIA59773.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142786
EMBL· GenBank· DDBJ
AIA59774.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142787
EMBL· GenBank· DDBJ
AIA59775.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142788
EMBL· GenBank· DDBJ
AIA59776.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142789
EMBL· GenBank· DDBJ
AIA59777.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142790
EMBL· GenBank· DDBJ
AIA59778.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142792
EMBL· GenBank· DDBJ
AIA59780.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142793
EMBL· GenBank· DDBJ
AIA59781.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142794
EMBL· GenBank· DDBJ
AIA59782.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142795
EMBL· GenBank· DDBJ
AIA59783.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142796
EMBL· GenBank· DDBJ
AIA59784.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142797
EMBL· GenBank· DDBJ
AIA59785.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142798
EMBL· GenBank· DDBJ
AIA59786.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142799
EMBL· GenBank· DDBJ
AIA59787.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142800
EMBL· GenBank· DDBJ
AIA59788.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142801
EMBL· GenBank· DDBJ
AIA59789.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ142802
EMBL· GenBank· DDBJ
AIA59790.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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