A0A059ZMR7 · A0A059ZMR7_ACIBA

Function

function

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

Catalytic activity

  • Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    EC:3.4.11.18 (UniProtKB | ENZYME | Rhea)

Cofactor

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site82substrate
Binding site100a divalent metal cation 1 (UniProtKB | ChEBI)
Binding site111a divalent metal cation 2 (UniProtKB | ChEBI); catalytic
Binding site111a divalent metal cation 1 (UniProtKB | ChEBI)
Binding site174a divalent metal cation 2 (UniProtKB | ChEBI); catalytic
Binding site181substrate
Binding site207a divalent metal cation 2 (UniProtKB | ChEBI); catalytic
Binding site238a divalent metal cation 2 (UniProtKB | ChEBI); catalytic
Binding site238a divalent metal cation 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioninitiator methionyl aminopeptidase activity
Molecular Functionmetalloaminopeptidase activity
Molecular Functiontransition metal ion binding
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methionine aminopeptidase
  • EC number
  • Short names
    MAP
    ; MetAP
  • Alternative names
    • Peptidase M

Gene names

    • Name
      map
    • Synonyms
      map1
      , map2
      , map_1
      , map_2
    • ORF names
      A7M90_02280
      , ABR2091_2078
      , ABUW_1778
      , B9W25_13105
      , B9X95_10175
      , CBE85_04275
      , CPI82_05110
      , CV954_008315
      , DOL94_16300
      , EA706_11030
      , EA722_09770
      , EJ062_13800
      , EKS29_08755
      , F2P40_10530
      , FJU79_17955
      , FPK81_03775
      , FQZ18_08635
      , G3N53_05090
      , GNY86_07715
      , GSE42_11495
      , H0529_03715
      , IAG11_02635
      , J6E47_08515
      , JHZ39_003343
      , MKP18_001300
      , P9867_010400
      , P9867_13545
      , SAMEA104305318_01850
      , SAMEA104305340_02502
      , SAMEA4394745_01632

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • AB5075-UW
    • R2091
    • XH647
    • DMS06669
    • KUFAR57
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex

Accessions

  • Primary accession
    A0A059ZMR7
  • Secondary accessions
    • B0V6C3

Proteomes

Subcellular Location

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-245Peptidase M24

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    264
  • Mass (Da)
    29,092
  • Last updated
    2014-09-03 v1
  • Checksum
    AD2322C55E84AC2D
MRASTVTIKTEQDLEKLRVSGRLAAQVLEMIGEYVKPGVTTEYLDNICNDYIVNTLKVIPANVGYHGFTKTICTSVNEVVCHGIPSQNKILKDGDIINIDVAIIKDGYFGDTSRMYYVGNVNPHAKKLVETTYEAMVAGIHAVKPGATLGDIGYAIQSVAHREGYSIVREYCGHGIGKVYHEQPNILHYGQRGQGLVLKKGMVFTIEPMVNAGKPQVKELNDGWTVITQDHSLSAQWEHMVAVTDTGFELLTPWPEGVGNYPEI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP008706
EMBL· GenBank· DDBJ
AKA31513.1
EMBL· GenBank· DDBJ
Genomic DNA
LN997846
EMBL· GenBank· DDBJ
CUW35480.1
EMBL· GenBank· DDBJ
Genomic DNA
AAYLMQ010000055
EMBL· GenBank· DDBJ
EGY2378915.1
EMBL· GenBank· DDBJ
Genomic DNA
ABFEVW020000007
EMBL· GenBank· DDBJ
EKU3567916.1
EMBL· GenBank· DDBJ
Genomic DNA
ABFEVW030000007
EMBL· GenBank· DDBJ
EMN1071013.1
EMBL· GenBank· DDBJ
Genomic DNA
JACSVK010000004
EMBL· GenBank· DDBJ
MBD0218786.1
EMBL· GenBank· DDBJ
Genomic DNA
JARTMM010000054
EMBL· GenBank· DDBJ
MDK4882678.1
EMBL· GenBank· DDBJ
Genomic DNA
VMAW01000001
EMBL· GenBank· DDBJ
MDT1910157.1
EMBL· GenBank· DDBJ
Genomic DNA
JARTMM020000001
EMBL· GenBank· DDBJ
MEC5496873.1
EMBL· GenBank· DDBJ
Genomic DNA
WIOC01000010
EMBL· GenBank· DDBJ
MQR49752.1
EMBL· GenBank· DDBJ
Genomic DNA
WPIP01000042
EMBL· GenBank· DDBJ
MVM91401.1
EMBL· GenBank· DDBJ
Genomic DNA
WWCH01000001
EMBL· GenBank· DDBJ
MYM78551.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAGTY010000004
EMBL· GenBank· DDBJ
NDW40444.1
EMBL· GenBank· DDBJ
Genomic DNA
LYKI01000012
EMBL· GenBank· DDBJ
OIG73491.1
EMBL· GenBank· DDBJ
Genomic DNA
NGEL01000114
EMBL· GenBank· DDBJ
OTM86556.1
EMBL· GenBank· DDBJ
Genomic DNA
NGKM01000002
EMBL· GenBank· DDBJ
OWK68137.1
EMBL· GenBank· DDBJ
Genomic DNA
NXDV01000003
EMBL· GenBank· DDBJ
PHQ03524.1
EMBL· GenBank· DDBJ
Genomic DNA
PHJU02000018
EMBL· GenBank· DDBJ
PQL84119.1
EMBL· GenBank· DDBJ
Genomic DNA
NEPB01000031
EMBL· GenBank· DDBJ
PRN33361.1
EMBL· GenBank· DDBJ
Genomic DNA
QKWF01000197
EMBL· GenBank· DDBJ
PZM11780.1
EMBL· GenBank· DDBJ
Genomic DNA
CP061525
EMBL· GenBank· DDBJ
QNV23380.1
EMBL· GenBank· DDBJ
Genomic DNA
CP059300
EMBL· GenBank· DDBJ
QOJ60769.1
EMBL· GenBank· DDBJ
Genomic DNA
CP072270
EMBL· GenBank· DDBJ
QTK45075.1
EMBL· GenBank· DDBJ
Genomic DNA
RFBY01000027
EMBL· GenBank· DDBJ
RSP75700.1
EMBL· GenBank· DDBJ
Genomic DNA
RFCO01000050
EMBL· GenBank· DDBJ
RSQ43370.1
EMBL· GenBank· DDBJ
Genomic DNA
RXLU01000082
EMBL· GenBank· DDBJ
RTQ74327.1
EMBL· GenBank· DDBJ
Genomic DNA
RXYO01000031
EMBL· GenBank· DDBJ
RTY11398.1
EMBL· GenBank· DDBJ
Genomic DNA
UFDJ01000006
EMBL· GenBank· DDBJ
SSI39501.1
EMBL· GenBank· DDBJ
Genomic DNA
UFMQ01000007
EMBL· GenBank· DDBJ
SST23006.1
EMBL· GenBank· DDBJ
Genomic DNA
UFNM01000010
EMBL· GenBank· DDBJ
SSU12229.1
EMBL· GenBank· DDBJ
Genomic DNA
VHEY01000073
EMBL· GenBank· DDBJ
TPS81387.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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