A0A059ZKK0 · A0A059ZKK0_ACIBA

  • Protein
    Dihydroorotate dehydrogenase (quinone)
  • Gene
    pyrD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.

Features

Showing features for binding site, active site.

133450100150200250300
Type
IDPosition(s)Description
Binding site59-63FMN (UniProtKB | ChEBI)
Binding site63substrate
Binding site83FMN (UniProtKB | ChEBI)
Binding site108-112substrate
Binding site136FMN (UniProtKB | ChEBI)
Binding site169FMN (UniProtKB | ChEBI)
Binding site169substrate
Active site172Nucleophile
Binding site174substrate
Binding site214FMN (UniProtKB | ChEBI)
Binding site242FMN (UniProtKB | ChEBI)
Binding site243-244substrate
Binding site265FMN (UniProtKB | ChEBI)
Binding site294FMN (UniProtKB | ChEBI)
Binding site315-316FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functiondihydroorotate dehydrogenase (quinone) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase (quinone)
  • EC number
  • Alternative names
    • DHOdehase
      (DHOD
      ; DHODase
      )
    • Dihydroorotate oxidase

Gene names

    • Name
      pyrD
    • ORF names
      A7M90_04455
      , ABUW_1444
      , AUO97_00165
      , B9W25_06085
      , B9X95_16450
      , CBE85_00105
      , CPI82_16085
      , DOL94_07630
      , F2P40_02370
      , FJU79_06185
      , FPK81_02145
      , FQZ18_06705
      , G3N53_09570
      , GNY86_18235
      , IAG11_02120
      , IHV20_12075
      , IMO23_12045
      , J6E47_06475
      , JHZ39_000851
      , MKP18_000375
      , SAMEA104305318_02922
      , SAMEA104305340_02012
      , SAMEA4394745_02000

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • ATCC 17978
    • ATCC 17978-VU
    • AB5075-UW
    • XH647
    • KUFAR57
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex

Accessions

  • Primary accession
    A0A059ZKK0

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Membrane

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain44-331Dihydroorotate dehydrogenase catalytic

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    334
  • Mass (Da)
    36,093
  • Last updated
    2014-09-03 v1
  • Checksum
    9D610BBC7CA7ECE1
MLYSLARPMLFSLAPERAHELTLSMLDKAHKLGMMRQTVEAKPTTCMGIEFPNPVGLAAGLDKNGAHIDALAGLGFGFIEIGTITPRPQSGNPKPRLFRIPEAKAIINRMGFNNDGVDKLIENVKASKFRGILGINIGKNADTPVEKAVDDYLICLEKVYNYASYITVNISSPNTKNLRSLQSGDALTELLQTLKARQLELAEQYNHYVPLVLKVAPDLTAEDVEFISAQLLDFKIDGLIVTNTTLSREGVENLPYGNESGGLSGAPVFEKSTECLRLFAQTLKGQIPLIGVGGILSGEQAAAKQQAGATLVQIYSGLIYTGPTLVKQCVEAMT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP008706
EMBL· GenBank· DDBJ
AKA31188.1
EMBL· GenBank· DDBJ
Genomic DNA
CP018664
EMBL· GenBank· DDBJ
APP29314.1
EMBL· GenBank· DDBJ
Genomic DNA
AAYLMQ010000007
EMBL· GenBank· DDBJ
EGY2376523.1
EMBL· GenBank· DDBJ
Genomic DNA
ABFEVW020000002
EMBL· GenBank· DDBJ
EKU3567012.1
EMBL· GenBank· DDBJ
Genomic DNA
ABFEVW030000002
EMBL· GenBank· DDBJ
EMN1070109.1
EMBL· GenBank· DDBJ
Genomic DNA
JACSVK010000003
EMBL· GenBank· DDBJ
MBD0218687.1
EMBL· GenBank· DDBJ
Genomic DNA
JACZEI010000027
EMBL· GenBank· DDBJ
MBE0330884.1
EMBL· GenBank· DDBJ
Genomic DNA
VMAW01000001
EMBL· GenBank· DDBJ
MDT1909845.1
EMBL· GenBank· DDBJ
Genomic DNA
WIOC01000002
EMBL· GenBank· DDBJ
MQR48183.1
EMBL· GenBank· DDBJ
Genomic DNA
WPIP01000216
EMBL· GenBank· DDBJ
MVM93476.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAGTY010000009
EMBL· GenBank· DDBJ
NDW41322.1
EMBL· GenBank· DDBJ
Genomic DNA
LYKI01000023
EMBL· GenBank· DDBJ
OIG72302.1
EMBL· GenBank· DDBJ
Genomic DNA
NGEL01000166
EMBL· GenBank· DDBJ
OTM81652.1
EMBL· GenBank· DDBJ
Genomic DNA
NGKM01000001
EMBL· GenBank· DDBJ
OWK68180.1
EMBL· GenBank· DDBJ
Genomic DNA
NXDV01000014
EMBL· GenBank· DDBJ
PHQ01732.1
EMBL· GenBank· DDBJ
Genomic DNA
NEPB01000008
EMBL· GenBank· DDBJ
PRN36056.1
EMBL· GenBank· DDBJ
Genomic DNA
QKWF01000070
EMBL· GenBank· DDBJ
PZM17739.1
EMBL· GenBank· DDBJ
Genomic DNA
CP061525
EMBL· GenBank· DDBJ
QNV23021.1
EMBL· GenBank· DDBJ
Genomic DNA
CP062919
EMBL· GenBank· DDBJ
QPF12335.1
EMBL· GenBank· DDBJ
Genomic DNA
CP072270
EMBL· GenBank· DDBJ
QTK44705.1
EMBL· GenBank· DDBJ
Genomic DNA
UFDJ01000008
EMBL· GenBank· DDBJ
SSI43176.1
EMBL· GenBank· DDBJ
Genomic DNA
UFMQ01000016
EMBL· GenBank· DDBJ
SST27447.1
EMBL· GenBank· DDBJ
Genomic DNA
UFNM01000007
EMBL· GenBank· DDBJ
SSU08714.1
EMBL· GenBank· DDBJ
Genomic DNA
VHEY01000019
EMBL· GenBank· DDBJ
TPS87132.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help