A0A059ZKK0 · A0A059ZKK0_ACIBA
- ProteinDihydroorotate dehydrogenase (quinone)
- GenepyrD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids334 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Catalytic activity
- (S)-dihydroorotate + a quinone = orotate + a quinol
Cofactor
Note: Binds 1 FMN per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 59-63 | FMN (UniProtKB | ChEBI) | |||
Binding site | 63 | substrate | |||
Binding site | 83 | FMN (UniProtKB | ChEBI) | |||
Binding site | 108-112 | substrate | |||
Binding site | 136 | FMN (UniProtKB | ChEBI) | |||
Binding site | 169 | FMN (UniProtKB | ChEBI) | |||
Binding site | 169 | substrate | |||
Active site | 172 | Nucleophile | |||
Binding site | 174 | substrate | |||
Binding site | 214 | FMN (UniProtKB | ChEBI) | |||
Binding site | 242 | FMN (UniProtKB | ChEBI) | |||
Binding site | 243-244 | substrate | |||
Binding site | 265 | FMN (UniProtKB | ChEBI) | |||
Binding site | 294 | FMN (UniProtKB | ChEBI) | |||
Binding site | 315-316 | FMN (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | dihydroorotate dehydrogenase (quinone) activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotate dehydrogenase (quinone)
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex
Accessions
- Primary accessionA0A059ZKK0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 44-331 | Dihydroorotate dehydrogenase catalytic | |||
Sequence similarities
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length334
- Mass (Da)36,093
- Last updated2014-09-03 v1
- Checksum9D610BBC7CA7ECE1
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP008706 EMBL· GenBank· DDBJ | AKA31188.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP018664 EMBL· GenBank· DDBJ | APP29314.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAYLMQ010000007 EMBL· GenBank· DDBJ | EGY2376523.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABFEVW020000002 EMBL· GenBank· DDBJ | EKU3567012.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABFEVW030000002 EMBL· GenBank· DDBJ | EMN1070109.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACSVK010000003 EMBL· GenBank· DDBJ | MBD0218687.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACZEI010000027 EMBL· GenBank· DDBJ | MBE0330884.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VMAW01000001 EMBL· GenBank· DDBJ | MDT1909845.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WIOC01000002 EMBL· GenBank· DDBJ | MQR48183.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPIP01000216 EMBL· GenBank· DDBJ | MVM93476.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAGTY010000009 EMBL· GenBank· DDBJ | NDW41322.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LYKI01000023 EMBL· GenBank· DDBJ | OIG72302.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NGEL01000166 EMBL· GenBank· DDBJ | OTM81652.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NGKM01000001 EMBL· GenBank· DDBJ | OWK68180.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NXDV01000014 EMBL· GenBank· DDBJ | PHQ01732.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NEPB01000008 EMBL· GenBank· DDBJ | PRN36056.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QKWF01000070 EMBL· GenBank· DDBJ | PZM17739.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP061525 EMBL· GenBank· DDBJ | QNV23021.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP062919 EMBL· GenBank· DDBJ | QPF12335.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP072270 EMBL· GenBank· DDBJ | QTK44705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFDJ01000008 EMBL· GenBank· DDBJ | SSI43176.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFMQ01000016 EMBL· GenBank· DDBJ | SST27447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFNM01000007 EMBL· GenBank· DDBJ | SSU08714.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VHEY01000019 EMBL· GenBank· DDBJ | TPS87132.1 EMBL· GenBank· DDBJ | Genomic DNA |