The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma.Liu C., Karam R., Zhou Y., Su F., Ji Y., Li G., Xu G., Lu L., Wang C.[...], Lu Y.View abstractCited forNUCLEOTIDE SEQUENCETissuePancreasCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCNat Med 20:596-598 (2014)Cited in9Mapped to11
UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2.Langer L.M., Kurscheidt K., Basquin J., Bonneau F., Iermak I., Basquin C., Conti E.View abstractAnnotationUPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCNucleic Acids Res 52:6036-6048 (2024)Mapped to26
UPF1 regulates mRNA stability by sensing poorly translated coding sequences.Musaev D., Abdelmessih M., Vejnar C.E., Yartseva V., Weiss L.A., Strayer E.C., Takacs C.M., Giraldez A.J.View abstractAnnotationUPF1 regulates mRNA stability by sensing poorly translated coding sequences.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCCell Rep 43:114074-114074 (2024)Mapped to20
UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency.Chapman J.H., Youle A.M., Grimme A.L., Neuman K.C., Hogg J.R.View abstractAnnotationUPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCNucleic Acids Res 52:5376-5391 (2024)Mapped to20
Nonsense-mediated mRNA decay affects hyperactive root formation in oculo- facio-cardio-dental syndrome via up-frameshift protein 1.Machida R., Ogawa T., Min Soe K., Moriyama K.View abstractAnnotationNonsense-mediated mRNA decay affects hyperactive root formation in oculo-facio-cardio-dental syndrome via up-frameshift protein 1.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCJ Oral Biosci 66:225-231 (2024)Mapped to20
Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells.Jung S., Ko S.H., Ahn N., Lee J., Park C.H., Hwang J.View abstractAnnotationRole of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCNat Commun 15:158-158 (2024)Mapped to21
LINC02561 promotes metastasis in HCC via HIF1-alpha/NDRG1/UPF1 axis.Li S.N., Li M.X., Guo W.W., Zhang L.R., Ding Y.H., Wu X.J.View abstractAnnotationLINC02561 promotes metastasis in HCC via HIF1-alpha/NDRG1/UPF1 axis.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCGene 896:148033-148033 (2024)Mapped to40
YTHDF2 facilitates aggresome formation via UPF1 in an m<sup>6</sup>A- independent manner.Hwang H.J., Park T.L., Kim H.I., Park Y., Kim G., Song C., Cho W.K., Kim Y.K.View abstractAnnotationYTHDF2 facilitates aggresome formation via UPF1 in an m[6]CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCNat Commun 14:6248-6248 (2023)Mapped to22
UPF1 regulates FOXO1 protein expression by promoting PBK transcription in non-small cell lung cancer.Wang P., Li T., Fang L., Chen D., Qi H., Gu C.View abstractAnnotationUPF1 regulates FOXO1 protein expression by promoting PBK transcription in non-small cell lung cancer.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCBiochem Biophys Res Commun 666:10-20 (2023)Mapped to21
LncRNA GAS5 regulated by FTO-mediated m6A demethylation promotes autophagic cell death in NSCLC by targeting UPF1/BRD4 axis.Fu Y., Liu L., Wu H., Zheng Y., Zhan H., Li L.View abstractAnnotationLncRNA GAS5 regulated by FTO-mediated m6A demethylation promotes autophagic cell death in NSCLC by targeting UPF1/BRD4 axis.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCMol Cell Biochem 479:553-566 (2024)Mapped to20
UPF1-From mRNA Degradation to Human Disorders.Staszewski J., Lazarewicz N., Konczak J., Migdal I., Maciaszczyk-Dziubinska E.View abstractAnnotationUPF1-From mRNA Degradation to Human Disorders.SourceGeneRif: 5976PubMedEurope PMCCells 12:419-419 (2023)Mapped to20
Modulation of RNA-binding properties of the RNA helicase UPF1 by its activator UPF2.Xue G., Maciej V.D., Machado de Amorim A., Pak M., Jayachandran U., Chakrabarti S.View abstractAnnotationModulation of RNA-binding properties of the RNA helicase UPF1 by its activator UPF2.CategoriesFunction, InteractionSourceGeneRif: 5976PubMedEurope PMCRNA 29:178-187 (2023)Mapped to25
Identification and Validation of UPF1 as a Novel Prognostic Biomarker in Renal Clear Cell Carcinoma.Wu C., Li H., Chang W., Zhong L., Zhang L., Wen Z., Mai S.View abstractAnnotationIdentification and Validation of UPF1 as a Novel Prognostic Biomarker in Renal Clear Cell Carcinoma.CategoriesFunction, ExpressionSourceGeneRif: 5976PubMedEurope PMCGenes (Basel) 13:2166-2166 (2022)Mapped to20
UPF1 increases amino acid levels and promotes cell proliferation in lung adenocarcinoma via the eIF2alpha-ATF4 axis.Fang L., Qi H., Wang P., Wang S., Li T., Xia T., Piao H., Gu C.View abstractAnnotationUPF1 increases amino acid levels and promotes cell proliferation in lung adenocarcinoma via the eIF2alpha-ATF4 axis.CategoriesFunction, ExpressionSourceGeneRif: 5976PubMedEurope PMCJ Zhejiang Univ Sci B 23:863-875 (2022)Mapped to20
The biological behavior of tRNA-derived fragment tRF-Leu-AAG in pancreatic cancer cells.Sui S., Wang Z., Cui X., Jin L., Zhu C.View abstractAnnotationThe biological behavior of tRNA-derived fragment tRF-Leu-AAG in pancreatic cancer cells.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCBioengineered 13:10617-10628 (2022)Mapped to20
An alternative UPF1 isoform drives conditional remodeling of nonsense- mediated mRNA decay.Fritz S.E., Ranganathan S., Wang C.D., Hogg J.R.View abstractAnnotationAn alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decay.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCEMBO J 41:e108898-e108898 (2022)Mapped to20
The edited UPF1 is correlated with elevated asparagine synthetase in pancreatic ductal adenocarcinomas.Hu J., Wang Z., Yang S., Lu Y., Li G.View abstractAnnotationThe edited UPF1 is correlated with elevated asparagine synthetase in pancreatic ductal adenocarcinomas.CategoriesFunction, Disease & VariantsSourceGeneRif: 5976PubMedEurope PMCMol Biol Rep 49:3713-3720 (2022)Mapped to22
Up-frameshift Protein 1 Promotes Tumor Progression by Regulating Apoptosis and Epithelial-Mesenchymal Transition of Colorectal Cancer.Chen B., Wang H., Li D., Lin X., Ma Z., Zeng Y.View abstractAnnotationUp-frameshift Protein 1 Promotes Tumor Progression by Regulating Apoptosis and Epithelial-Mesenchymal Transition of Colorectal Cancer.CategoriesFunction, ExpressionSourceGeneRif: 5976PubMedEurope PMCTechnol Cancer Res Treat 20:15330338211064438-15330338211064438 (2021)Mapped to20
A role for AKT1 in nonsense-mediated mRNA decay.Palma M., Leroy C., Salome-Desnoulez S., Werkmeister E., Kong R., Mongy M., Le Hir H., Lejeune F.View abstractAnnotationA role for AKT1 in nonsense-mediated mRNA decay.CategoriesPTM / Processing, InteractionSourceGeneRif: 5976PubMedEurope PMCNucleic Acids Res 49:11022-11037 (2021)Mapped to34
UPF1 impacts on mTOR signaling pathway and autophagy in endometrioid endometrial carcinoma.Zhang M., Chen H., Qin P., Cai T., Li L., Chen R., Liu S., Chen H., Lin W.[...], Jiang Q.View abstractAnnotationUPF1 impacts on mTOR signaling pathway and autophagy in endometrioid endometrial carcinoma.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCAging (Albany NY) 13:21202-21215 (2021)Mapped to26
UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair.Ngo G.H.P., Grimstead J.W., Baird D.M.View abstractAnnotationUPF1 promotes the formation of R loops to stimulate DNA double-strand break repair.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCNat Commun 12:3849-3849 (2021)Mapped to20
UPF1: a potential biomarker in human cancers.Chen B.L., Wang H.M., Lin X.S., Zeng Y.M.View abstractAnnotationUPF1: a potential biomarker in human cancers.SourceGeneRif: 5976PubMedEurope PMCFront Biosci (Landmark Ed) 26:76-84 (2021)Mapped to20
UPF1 promotes chemoresistance to oxaliplatin through regulation of TOP2A activity and maintenance of stemness in colorectal cancer.Zhu C., Zhang L., Zhao S., Dai W., Xu Y., Zhang Y., Zheng H., Sheng W., Xu Y.View abstractAnnotationUPF1 promotes chemoresistance to oxaliplatin through regulation of TOP2A activity and maintenance of stemness in colorectal cancer.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCCell Death Dis 12:519-519 (2021)Mapped to20
UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense- mediated decay dysfunction.Zaepfel B.L., Zhang Z., Maulding K., Coyne A.N., Cheng W., Hayes L.R., Lloyd T.E., Sun S., Rothstein J.D.View abstractAnnotationUPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction.CategoryFunctionSourceGeneRif: 5976PubMedEurope PMCCell Rep 34:108925-108925 (2021)Mapped to24
The origins and consequences of <i>UPF1</i> variants in pancreatic adenosquamous carcinoma.Polaski J.T., Udy D.B., Escobar-Hoyos L.F., Askan G., Leach S.D., Ventura A., Kannan R., Bradley R.K.View abstractAnnotationThe origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma.SourceGeneRif: 5976PubMedEurope PMCElife 10:e62209-e62209 (2021)Mapped to20