A0A059TEP8 · A0A059TEP8_MIOTA

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentmembrane raft
Molecular Functioncoreceptor activity
Molecular FunctionMHC class II protein binding
Molecular Functionprotein tyrosine kinase binding
Biological Processadaptive immune response
Biological Processcell adhesion
Biological Processinterleukin-15-mediated signaling pathway
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological ProcessT cell activation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    T-cell surface glycoprotein CD4
  • Alternative names
    • T-cell surface antigen T4/Leu-3

Organism names

Accessions

  • Primary accession
    A0A059TEP8

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane397-420Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-25
ChainPRO_500158264826-426T-cell surface glycoprotein CD4

Keywords

Interaction

Subunit

Forms disulfide-linked homodimers at the cell surface. Interacts with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes. Interacts (via Ig-like V-type domain) with MHCII alpha chain (via alpha-2 domain) and beta chain (via beta-2 domain); this interaction increases the affinity of TCR for peptide-MHCII. CD4 oligomerization via Ig-like C2-type 2 and 3 domains appears to be required for stable binding to MHCII and adhesion between T cells and APCs.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-119Ig-like

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    426
  • Mass (Da)
    47,299
  • Last updated
    2014-09-03 v1
  • Checksum
    959EF708AA597031
MNRGIPFRHLLLVLQLALLPAVTQGKKVVLGKKGDTVELTCNASQKKNTQFHWKNSNQIKILGNQGSFLTKGPSKLSDRADSRKSLWDQGCFSMIIKNLKIEDSETYICEVEDKKEEVELLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVKCRSPRGKNIQGGRTLSVPQLERQDSGTWTCTVSQDQKTVEFKIDIVVLAFQKASSTVYKKEGEQVEFSFPLAFTLEKLTGSGELWWQAERASSSKSWITFDLNNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQFQENLTCEVWGPTSPKLTLSLKLENKEATVSKQAKAVWVLNPEAGMWQCLLRDSGQVLLESNIKVLPTWPTPVQPMALIVLGGVAGLLLFTGLGIFFCVRCRHRR

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue426

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ531716
EMBL· GenBank· DDBJ
AHY35174.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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