A0A059T9M0 · A0A059T9M0_RHIPS
- ProteinTyrosine aminotransferase
- GeneTat
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids454 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
Catalytic activity
- 2-oxoglutarate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
Cofactor
Pathway
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | L-tyrosine:2-oxoglutarate aminotransferase activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | biosynthetic process | |
Biological Process | L-phenylalanine catabolic process | |
Biological Process | tyrosine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine aminotransferase
- EC number
- Short namesTAT
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yinpterochiroptera > Rhinolophoidea > Rhinolophidae > Rhinolophinae > Rhinolophus
Accessions
- Primary accessionA0A059T9M0
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 280 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 28-44 | Basic and acidic residues | ||||
Sequence: NSKQEKVKGRKARWSVK | ||||||
Region | 28-47 | Disordered | ||||
Sequence: NSKQEKVKGRKARWSVKPSD | ||||||
Domain | 73-434 | Aminotransferase class I/classII | ||||
Sequence: MIALSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGYLSSREEIASYYHCPEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILIPRPGFSLYRTLAESMGIEVKLYNLLPEKSWEIDLKQLESLIDEKTACLIVNNPSNPCGSVFSTNHLQKILAVAARQCVPILADEIYGDMVFSDSKFEPLATLSSNVPILSCGGLAKRWLVPGWRLGWILIHDRKDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILHRTPQEFYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYLMVEIEMEHFPEFKNDVEFTERLVAEQSVHCLPATCFEYPNFFRVVITVPEVMMLEACSRI |
Sequence similarities
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length454
- Mass (Da)50,502
- Last updated2014-09-03 v1
- Checksum777B88062015EC3F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 28-44 | Basic and acidic residues | ||||
Sequence: NSKQEKVKGRKARWSVK |