A0A037YDD8 · A0A037YDD8_ECOLX

  • Protein
    Acetyl-coenzyme A synthetase
  • Gene
    acs
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site191-194CoA (UniProtKB | ChEBI)
Binding site311CoA (UniProtKB | ChEBI)
Binding site335CoA (UniProtKB | ChEBI)
Binding site387-389ATP (UniProtKB | ChEBI)
Binding site411-416ATP (UniProtKB | ChEBI)
Binding site500ATP (UniProtKB | ChEBI)
Binding site515ATP (UniProtKB | ChEBI)
Binding site523CoA (UniProtKB | ChEBI)
Binding site526ATP (UniProtKB | ChEBI)
Binding site537Mg2+ (UniProtKB | ChEBI)
Binding site539Mg2+ (UniProtKB | ChEBI)
Binding site542Mg2+ (UniProtKB | ChEBI)
Binding site584CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionacetate-CoA ligase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processacetyl-CoA biosynthetic process from acetate
Biological Processchemotaxis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acetyl-coenzyme A synthetase
  • EC number
  • Short names
    AcCoA synthetase
    ; Acs
  • Alternative names
    • Acetate--CoA ligase
    • Acyl-activating enzyme

Gene names

    • Name
      acs
    • ORF names
      ABT96_003384
      , ACW72_002485
      , BCB93_001128
      , BGZ_01733
      , BK383_04565
      , BvCmsNSP007_02413
      , C2R31_001855
      , C719_004044
      , CIG67_08660
      , CLG78_001761
      , DL968_18400
      , G6Z99_18980
      , HJS37_003453
      , HLZ50_12515
      , IFN33_000626
      , NCTC10082_01987
      , NCTC9706_01910
      , TUM18780_40830

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 570
    • 376025
    • 412057
    • CCPM 6219
    • AMC_686
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    A0A037YDD8

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue609N6-acetyllysine

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-81Acetyl-coenzyme A synthetase N-terminal
Domain83-467AMP-dependent synthetase/ligase
Domain531-609AMP-binding enzyme C-terminal

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    652
  • Mass (Da)
    72,066
  • Last updated
    2014-07-09 v1
  • Checksum
    4DCA1C1990D6FC6A
MSQIHKHTIPANIADRCLINPQQYEAMYQQSINAPDTFWGEQGKILDWIKPYQKVKNTSFAPGNVSIKWYEDGTLNLAANCLDRHLQENGDRTAIIWEGDDASQSKHISYKELHRDVCRFANTLLELGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSNSRLVITSDEGVRAGRSIPLKKNVDDALKNPNVTSVEHVVVLKRTGGKIDWQEGRDLWWHDLVEQASDQHQAEEMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAALTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGPLACGATTLMFEGVPNWPTPARMAQVVDKHQVNILYTAPTAIRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWYWKKIGNEKCPVVDTWWQTETGGFMITPLPGATELKAGSATRPFFGVQPALVDNEGNPLEGATEGSLVITDSWPGQARTLFGDHERFEQTYFSTFKNMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPHNIKGQAIYAYVTLNHGEEPSPELYAEVRNWVRKEIGPLATPDVLHWTDSLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPGVVEKLLEEKQAIAMPS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP023197
EMBL· GenBank· DDBJ
BCG38921.1
EMBL· GenBank· DDBJ
Genomic DNA
AASCBU010000006
EMBL· GenBank· DDBJ
EFA8784043.1
EMBL· GenBank· DDBJ
Genomic DNA
AASLUY010000008
EMBL· GenBank· DDBJ
EFE0299542.1
EMBL· GenBank· DDBJ
Genomic DNA
AASZRA010000004
EMBL· GenBank· DDBJ
EFI6951537.1
EMBL· GenBank· DDBJ
Genomic DNA
AATGUC010000011
EMBL· GenBank· DDBJ
EFL0833246.1
EMBL· GenBank· DDBJ
Genomic DNA
AATHUK010000021
EMBL· GenBank· DDBJ
EFL4330458.1
EMBL· GenBank· DDBJ
Genomic DNA
AATJOC010000016
EMBL· GenBank· DDBJ
EFM0254810.1
EMBL· GenBank· DDBJ
Genomic DNA
AAVTXU010000082
EMBL· GenBank· DDBJ
EGE1989555.1
EMBL· GenBank· DDBJ
Genomic DNA
BGDN01000082
EMBL· GenBank· DDBJ
GDP74450.1
EMBL· GenBank· DDBJ
Genomic DNA
DABESF010000015
EMBL· GenBank· DDBJ
HAI5419915.1
EMBL· GenBank· DDBJ
Genomic DNA
DABGKZ010000015
EMBL· GenBank· DDBJ
HAJ5150844.1
EMBL· GenBank· DDBJ
Genomic DNA
DABUSX010000004
EMBL· GenBank· DDBJ
HAN5764410.1
EMBL· GenBank· DDBJ
Genomic DNA
MOKI01000006
EMBL· GenBank· DDBJ
OJR56210.1
EMBL· GenBank· DDBJ
Genomic DNA
CP049201
EMBL· GenBank· DDBJ
QIF14864.1
EMBL· GenBank· DDBJ
Genomic DNA
NPIM01000112
EMBL· GenBank· DDBJ
RVE14292.1
EMBL· GenBank· DDBJ
Genomic DNA
UFZA01000001
EMBL· GenBank· DDBJ
STE03633.1
EMBL· GenBank· DDBJ
Genomic DNA
UGGJ01000004
EMBL· GenBank· DDBJ
STN84879.1
EMBL· GenBank· DDBJ
Genomic DNA
CABWJB010000001
EMBL· GenBank· DDBJ
VWM62281.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp