A0A031LPM7 · A0A031LPM7_9CREN

Function

function

Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Pathway

Protein modification; peptidyl-diphthamide biosynthesis.

GO annotations

AspectTerm
Molecular Function2-(3-amino-3-carboxypropyl)histidine synthase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Biological Processprotein histidyl modification to diphthamide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-(3-amino-3-carboxypropyl)histidine synthase
  • EC number

Gene names

    • ORF names
      CM19_06210

Organism names

Accessions

  • Primary accession
    A0A031LPM7

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the DPH1/DPH2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    332
  • Mass (Da)
    38,149
  • Last updated
    2014-07-09 v1
  • Checksum
    521FF00BEFFD2351
MSYFFEQEFIINEIVKRGSRKVLLQFPEGLRYFSTEIVSTLEKSLPDVQFIISGEPSWGACDIAEDEAQILGVDLIVHFGHTPYTWYYPKFPTLFVKTTSKIEINERWIDEILGKVRKYNPKVISLSSTIQHSTLLSEIKERLTNNFRIIIGKPSNPFMMDGQILGCDYKAIPQDVDLHLNVSGGVFHPIGIGLTTGKPVINLDPYSGKVEDLTEEIRKILKIRYSKIMQAFDARTWIIIQGIKVGQNRPLMVKYMEKKLKERGNTVYIMSNKVLNIDTLRNIDRKYVDAYIVTSCPRLPTDDLFSFEKPVLTPGEAKMVINNSLEPYIFPW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JFZT01000039
EMBL· GenBank· DDBJ
EZQ06951.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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