A0A026WSW2 · A0A026WSW2_OOCBI

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Lipid metabolism; leukotriene B4 biosynthesis.

Features

Showing features for binding site, active site.

161150100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site294Zn2+ (UniProtKB | ChEBI); catalytic
Active site295Proton acceptor
Binding site298Zn2+ (UniProtKB | ChEBI); catalytic
Binding site317Zn2+ (UniProtKB | ChEBI); catalytic
Active site382Proton donor
Binding site563-565a peptide (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentplasma membrane
Cellular Componentside of membrane
Molecular Functionaminopeptidase activity
Molecular Functionepoxide hydrolase activity
Molecular Functionleukotriene-A4 hydrolase activity
Molecular Functionmetallopeptidase activity
Molecular Functionzinc ion binding
Biological Processleukotriene biosynthetic process
Biological Processpeptide catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Leukotriene A(4) hydrolase
  • EC number
  • Short names
    LTA-4 hydrolase

Gene names

    • ORF names
      X777_14935

Organism names

Accessions

  • Primary accession
    A0A026WSW2

Proteomes

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor
Cytoplasm
Membrane
; Lipid-anchor, GPI-anchor

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain462-607Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal

Sequence similarities

Belongs to the peptidase M1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    611
  • Mass (Da)
    68,963
  • Last updated
    2014-07-09 v1
  • Checksum
    F9C624C21EB49E7C
MALSPGDPSSFANPEFAIVTHTHLELNVDFDQKILQGKAILDIERTSSAATEVILDSRELVISSATSDGSSLEHHIGADVEFGSKLVIQLPSAAGNNNTKCKIEIEYKTSPNATALKWLTAEQTAGGVHPYLFSQCHAIHARSMFPCQDTPSVKSTYSAKISVPRELTVVMSALLDGVSDLGSDKKVYEFRQPVPIPSYLVAIAVGALVAKQIGPRSKVWAEKEFIDQSAYEFGETETMLQIAEQLCGPYVWGMYDILVLPPSFAFGGMENPCLTFVTPTILAGDRSLANVIAHEISHSWTGNLVTNANFEHFWLNEGFTMFVERKINSRMFGEKMRHFEALHGIGCLREGIQTLGETNQLTNLVPNLAGVDPDDAFSIVPYEKGHTFLFYLEQLLGGSEVFEPFLKSYLDTFKYRSIKTDTWKDYLYKYFSDKIKLLNSVDWDTWLYKPGMPPVIPNYDKSLTNVCTELAKRWIEWKEISTSTFMKSDIDSLSPAQKVAFLTELHKSSVNLSLDKMQVMADTYQLDSIKNSEIRFIWLRLCIKNRWKSKVDDALAFATEQGRMKYVRPIFRDLYEWEAMRQRAIDIYLSKKNKMMYVTAHAVAKDLHLSD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KK107119
EMBL· GenBank· DDBJ
EZA58766.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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