A0A026W182 · ORCO_OOCBI

Function

function

Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
Obligate coreceptor of all odorant receptors (By similarity).
Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Can form functional ion channels in the absence of an odor-binding odorant receptor (By similarity).
Plays a central role in the perception of olfactory stimuli in ants and is essential for ant social organization (PubMed:28802042).
Required for pheromone sensing (PubMed:28802042).
Also required for the development and maintenance of odorant receptor neurons (ORNs) and of antennal lobe glomeruli (PubMed:28802042).

Miscellaneous

In contrast to other ant species, C.biroi ants reproduce via parthenogenesis, enabling stable germline modifications from the clonal progeny of injected individuals without laboratory crosses.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionodorant binding
Molecular Functionolfactory receptor activity
Biological Processantennal development
Biological Processdetection of chemical stimulus involved in sensory perception of smell
Biological Processdetection of pheromone
Biological Processolfactory behavior
Biological Processresponse to pheromone
Biological Processsignal transduction
Biological Processsocial behavior

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Odorant receptor coreceptor

Gene names

    • Name
      Orco
    • ORF names
      X777_12371

Organism names

Accessions

  • Primary accession
    A0A026W182

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-43Cytoplasmic
Transmembrane44-64Helical; Name=1
Topological domain65-73Extracellular
Transmembrane74-94Helical; Name=2
Topological domain95-133Cytoplasmic
Transmembrane134-154Helical; Name=3
Topological domain155-190Extracellular
Transmembrane191-211Helical; Name=4
Topological domain212-349Cytoplasmic
Transmembrane350-370Helical; Name=5
Topological domain371-382Extracellular
Transmembrane383-403Helical; Name=6
Topological domain404-454Cytoplasmic
Transmembrane455-475Helical; Name=7
Topological domain476-478Extracellular

Keywords

Phenotypes & Variants

Disruption phenotype

Impaired behavior and fitness, probably due to loss of pheromone sensing. Ants also display gross neuroanatomical defects in the antennal lobe, with a dramatic decrease in the number of antennal lobe glomeruli.

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00004420031-478Odorant receptor coreceptor
Glycosylation167N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Tissue specificity

Present in antennae (at protein level).

Interaction

Subunit

Heterodimer with conventional odorant receptors (ORs).

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region261-281Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    478
  • Mass (Da)
    54,109
  • Last updated
    2014-07-09 v1
  • Checksum
    C35E3F2B46573CF0
MMKMKQQGLVADLLPNIRVMKTFGHFVFNYYNDNSSKYLHKVYCCVNLFMLLLQFGLCAVNLIVESADVDDLTANTITLLFFTHSIVKICYFAIRSKYFYRTWAIWNNPNSHPLFAESNARYHAIALKKMRLLLFLVGGTTMLAAVAWTVLTFFEHPIRKIVDPVTNETEIIELPQLLIRSFYPFDAGKGITHVLVLVYQFYWVLFMLIDANSLDVLFCSWLLFACEQLQHLKQIMKPLMELSATLDTVVPNSSELFKAGSADHLRDGDNPPPPPPPQSDNMLDLDLRNIYSNRQDFTATFRPTAGMTFNGGVGPNGLTKKQEALVRSAIKYWVERHKHIVRLVTAVGDAYGFALLLHMLTTTITLTLLAYQATKVNGINVYAASTIGYILYTFGQVFLFCIFGNRLIEESTSVMEAAYSCHWYDGSEEAKTFVQIVCQQCQKAMSISGAKFFTVSLDLFASVLGAVVTYFMVLVQLK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KK107522
EMBL· GenBank· DDBJ
EZA49341.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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