A0A026W182 · ORCO_OOCBI
- ProteinOdorant receptor coreceptor
- GeneOrco
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids478 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
Obligate coreceptor of all odorant receptors (By similarity).
Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Can form functional ion channels in the absence of an odor-binding odorant receptor (By similarity).
Plays a central role in the perception of olfactory stimuli in ants and is essential for ant social organization (PubMed:28802042).
Required for pheromone sensing (PubMed:28802042).
Also required for the development and maintenance of odorant receptor neurons (ORNs) and of antennal lobe glomeruli (PubMed:28802042).
Obligate coreceptor of all odorant receptors (By similarity).
Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Can form functional ion channels in the absence of an odor-binding odorant receptor (By similarity).
Plays a central role in the perception of olfactory stimuli in ants and is essential for ant social organization (PubMed:28802042).
Required for pheromone sensing (PubMed:28802042).
Also required for the development and maintenance of odorant receptor neurons (ORNs) and of antennal lobe glomeruli (PubMed:28802042).
Miscellaneous
In contrast to other ant species, C.biroi ants reproduce via parthenogenesis, enabling stable germline modifications from the clonal progeny of injected individuals without laboratory crosses.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | odorant binding | |
Molecular Function | olfactory receptor activity | |
Biological Process | antennal development | |
Biological Process | detection of chemical stimulus involved in sensory perception of smell | |
Biological Process | detection of pheromone | |
Biological Process | olfactory behavior | |
Biological Process | response to pheromone | |
Biological Process | signal transduction | |
Biological Process | social behavior |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameOdorant receptor coreceptor
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Formicoidea > Formicidae > Dorylinae > Ooceraea
Accessions
- Primary accessionA0A026W182
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-43 | Cytoplasmic | ||||
Sequence: MMKMKQQGLVADLLPNIRVMKTFGHFVFNYYNDNSSKYLHKVY | ||||||
Transmembrane | 44-64 | Helical; Name=1 | ||||
Sequence: CCVNLFMLLLQFGLCAVNLIV | ||||||
Topological domain | 65-73 | Extracellular | ||||
Sequence: ESADVDDLT | ||||||
Transmembrane | 74-94 | Helical; Name=2 | ||||
Sequence: ANTITLLFFTHSIVKICYFAI | ||||||
Topological domain | 95-133 | Cytoplasmic | ||||
Sequence: RSKYFYRTWAIWNNPNSHPLFAESNARYHAIALKKMRLL | ||||||
Transmembrane | 134-154 | Helical; Name=3 | ||||
Sequence: LFLVGGTTMLAAVAWTVLTFF | ||||||
Topological domain | 155-190 | Extracellular | ||||
Sequence: EHPIRKIVDPVTNETEIIELPQLLIRSFYPFDAGKG | ||||||
Transmembrane | 191-211 | Helical; Name=4 | ||||
Sequence: ITHVLVLVYQFYWVLFMLIDA | ||||||
Topological domain | 212-349 | Cytoplasmic | ||||
Sequence: NSLDVLFCSWLLFACEQLQHLKQIMKPLMELSATLDTVVPNSSELFKAGSADHLRDGDNPPPPPPPQSDNMLDLDLRNIYSNRQDFTATFRPTAGMTFNGGVGPNGLTKKQEALVRSAIKYWVERHKHIVRLVTAVGD | ||||||
Transmembrane | 350-370 | Helical; Name=5 | ||||
Sequence: AYGFALLLHMLTTTITLTLLA | ||||||
Topological domain | 371-382 | Extracellular | ||||
Sequence: YQATKVNGINVY | ||||||
Transmembrane | 383-403 | Helical; Name=6 | ||||
Sequence: AASTIGYILYTFGQVFLFCIF | ||||||
Topological domain | 404-454 | Cytoplasmic | ||||
Sequence: GNRLIEESTSVMEAAYSCHWYDGSEEAKTFVQIVCQQCQKAMSISGAKFFT | ||||||
Transmembrane | 455-475 | Helical; Name=7 | ||||
Sequence: VSLDLFASVLGAVVTYFMVLV | ||||||
Topological domain | 476-478 | Extracellular | ||||
Sequence: QLK |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Impaired behavior and fitness, probably due to loss of pheromone sensing. Ants also display gross neuroanatomical defects in the antennal lobe, with a dramatic decrease in the number of antennal lobe glomeruli.
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000442003 | 1-478 | Odorant receptor coreceptor | |||
Sequence: MMKMKQQGLVADLLPNIRVMKTFGHFVFNYYNDNSSKYLHKVYCCVNLFMLLLQFGLCAVNLIVESADVDDLTANTITLLFFTHSIVKICYFAIRSKYFYRTWAIWNNPNSHPLFAESNARYHAIALKKMRLLLFLVGGTTMLAAVAWTVLTFFEHPIRKIVDPVTNETEIIELPQLLIRSFYPFDAGKGITHVLVLVYQFYWVLFMLIDANSLDVLFCSWLLFACEQLQHLKQIMKPLMELSATLDTVVPNSSELFKAGSADHLRDGDNPPPPPPPQSDNMLDLDLRNIYSNRQDFTATFRPTAGMTFNGGVGPNGLTKKQEALVRSAIKYWVERHKHIVRLVTAVGDAYGFALLLHMLTTTITLTLLAYQATKVNGINVYAASTIGYILYTFGQVFLFCIFGNRLIEESTSVMEAAYSCHWYDGSEEAKTFVQIVCQQCQKAMSISGAKFFTVSLDLFASVLGAVVTYFMVLVQLK | ||||||
Glycosylation | 167 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Expression
Tissue specificity
Present in antennae (at protein level).
Interaction
Subunit
Heterodimer with conventional odorant receptors (ORs).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 261-281 | Disordered | ||||
Sequence: SADHLRDGDNPPPPPPPQSDN |
Sequence similarities
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Orco subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length478
- Mass (Da)54,109
- Last updated2014-07-09 v1
- ChecksumC35E3F2B46573CF0
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KK107522 EMBL· GenBank· DDBJ | EZA49341.1 EMBL· GenBank· DDBJ | Genomic DNA |