Retinoic acid induces leukemia cell G1 arrest and transition into differentiation by inhibiting cyclin-dependent kinase-activating kinase binding and phosphorylation of PML/RARalpha.
- AnnotationIn response to ATRA PML/RARalpha is dissociated from CAK leading to MAT1 degradation G1 arrest and decreased CAK phosphorylation of PML/RARalpha
- CategoriesFunction, PTM / Processing
- SourceGeneRif: 4331