Beclin1 mRNA and protein were significantly increased in spermatozoa from infertile patients of different etiologies in comparison to healthy controls. However DYNLT1 mRNA expression was significantly decreased in infertile groups than controls. Mature spermatozoa extracted from all studied subjects showed increased DYNLT1 mRNA and decreased Beclin1 mRNA and protein expression compared with the whole sample.
The results suggest that autophagy-associated proteins LC3A LC3B and Beclin-1 might be potential biomarkers for subclassification differentiation and local metastasis in primary lung tumor.
Results show that the expression of AMBRA1 and Beclin-1 is increased in human gastric adenocarcinoma (GC) tissues. High protein expression of AMBRA1 and Beclin-1 is correlated with tumor invasion and is an independent poor prognostic marker in GC patients.
These results demonstrate that Beclin1 acts as a tumour suppressor in the development or progression of OTSCC and that Beclin1 may represent a novel prognostic marker for patients with OTSCC.
Beclin-1 was overexpressed in colorectal cancer tissues and was correlated with lower levels of miR-30a. Patients with higher Beclin-1 expression levels had higher survival rates than patients with lower Beclin-1 expression levels.
significantly different gene expressions of BECN1 and PRKCB between the control and the Alzheimer's disease (AD) groups and of CDKN2A between the control and the preclinical AD groups are reported.
Our findings that reduced Beclin-1 and high HIF-1alpha expression are associated with the development and progression of HCC may provide molecular therapeutic targets toward inhibiting HCC development and progression.
High expression of beclin-1 in papillary thyroid carcinoma and metastatic lymph node suggest that neo-expression of beclin-1 may play a role in tumorigenesis and lymph node metastasis in human papillary thyroid carcinoma.
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