A0A024R0A8 · A0A024R0A8_HUMAN
- ProteinAdenosylhomocysteinase
- GeneAHCYL1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids530 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 155 | substrate | |||
Binding site | 229 | substrate | |||
Binding site | 254 | substrate | |||
Binding site | 284 | substrate | |||
Binding site | 288 | substrate | |||
Binding site | 320-325 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 341 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 444 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum | |
Molecular Function | enzyme regulator activity | |
Molecular Function | hydrolase activity | |
Biological Process | epithelial fluid transport | |
Biological Process | one-carbon metabolic process | |
Biological Process | positive regulation of sodium ion transport | |
Biological Process | protein export from nucleus | |
Biological Process | regulation of monoatomic anion transport | |
Biological Process | regulation of mRNA 3'-end processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosylhomocysteinase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A024R0A8
- Secondary accessions
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Organism-specific databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 53-103 | Disordered | |||
Compositional bias | 55-85 | Polar residues | |||
Domain | 289-450 | S-adenosyl-L-homocysteine hydrolase NAD binding | |||
Sequence similarities
Belongs to the adenosylhomocysteinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length530
- Mass (Da)58,951
- Last updated2014-07-09 v1
- Checksum974D23361A245D04
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 55-85 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GQ900917 EMBL· GenBank· DDBJ | ADO22434.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471122 EMBL· GenBank· DDBJ | EAW56425.1 EMBL· GenBank· DDBJ | Genomic DNA |