A0A024R0A8 · A0A024R0A8_HUMAN

  • Protein
    Adenosylhomocysteinase
  • Gene
    AHCYL1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Note: Binds 1 NAD+ per subunit.

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.

Features

Showing features for binding site.

153050100150200250300350400450500
TypeIDPosition(s)Description
Binding site155substrate
Binding site229substrate
Binding site254substrate
Binding site284substrate
Binding site288substrate
Binding site320-325NAD+ (UniProtKB | ChEBI)
Binding site341NAD+ (UniProtKB | ChEBI)
Binding site444NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Molecular Functionenzyme regulator activity
Molecular Functionhydrolase activity
Biological Processepithelial fluid transport
Biological Processone-carbon metabolic process
Biological Processpositive regulation of sodium ion transport
Biological Processprotein export from nucleus
Biological Processregulation of monoatomic anion transport
Biological Processregulation of mRNA 3'-end processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosylhomocysteinase
  • EC number

Gene names

    • Name
      AHCYL1
    • ORF names
      hCG_38162

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A024R0A8
  • Secondary accessions
    • A0A384N6B4

Organism-specific databases

Subcellular Location

Disease & Variants

Organism-specific databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region53-103Disordered
Compositional bias55-85Polar residues
Domain289-450S-adenosyl-L-homocysteine hydrolase NAD binding

Sequence similarities

Belongs to the adenosylhomocysteinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    530
  • Mass (Da)
    58,951
  • Last updated
    2014-07-09 v1
  • Checksum
    974D23361A245D04
MSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKQIQFADDMQEFTKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSSDDEVSPREKQQTNSKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELTDDQAKYLGLNKNGPFKPNYYRY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias55-85Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ900917
EMBL· GenBank· DDBJ
ADO22434.1
EMBL· GenBank· DDBJ
mRNA
CH471122
EMBL· GenBank· DDBJ
EAW56425.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help