A0A024L2W8 · A0A024L2W8_ECOLX
- ProteinGamma-aminobutyraldehyde dehydrogenase
- GenepatD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids474 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
Miscellaneous
4-aminobutanal can spontaneously cyclize to 1-pyrroline, and 5-aminopentanal to 1-piperideine.
Catalytic activity
- 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+
- 5-aminopentanal + NAD+ + H2O = 5-aminopentanoate + NADH + 2 H+
Pathway
Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1.
Amino-acid degradation.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 146-148 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 172-175 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 209 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 225-228 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 246 | ||||
Active site | 280 | Nucleophile | |||
Binding site | 280 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | aminobutyraldehyde dehydrogenase (NAD+) activity | |
Molecular Function | NAD binding | |
Biological Process | L-lysine catabolic process | |
Biological Process | putrescine catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGamma-aminobutyraldehyde dehydrogenase
- EC number
- Short namesABALDH
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionA0A024L2W8
- Secondary accessions
Proteomes
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 13-470 | Aldehyde dehydrogenase | |||
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length474
- Mass (Da)50,860
- Last updated2014-07-09 v1
- MD5 ChecksumA5910205E128DA53CCBD48DD02F8A97B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP026399 EMBL· GenBank· DDBJ | AUY01109.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASEBA010000058 EMBL· GenBank· DDBJ | EFC9751896.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASWOY010000030 EMBL· GenBank· DDBJ | EFH6649744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABLFQU030000031 EMBL· GenBank· DDBJ | EMM0026614.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABHXT010000030 EMBL· GenBank· DDBJ | HAJ5960048.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DADUEU010000029 EMBL· GenBank· DDBJ | HBB1575009.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LDYI01000120 EMBL· GenBank· DDBJ | KPO09259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACGTG010000001 EMBL· GenBank· DDBJ | MBA6240873.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACZOI010000027 EMBL· GenBank· DDBJ | MBE0977861.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RYCF01000062 EMBL· GenBank· DDBJ | MQK25956.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SQQU01000050 EMBL· GenBank· DDBJ | MQS33062.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WSXK01000059 EMBL· GenBank· DDBJ | MWF97071.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTQQ01000079 EMBL· GenBank· DDBJ | MWR88318.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTRC01000053 EMBL· GenBank· DDBJ | MWT20578.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTRX01000036 EMBL· GenBank· DDBJ | MWU32818.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WUIY01000200 EMBL· GenBank· DDBJ | MXI76711.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WUIG01000421 EMBL· GenBank· DDBJ | MXJ10201.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAGYI010000021 EMBL· GenBank· DDBJ | NEM86710.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MPAF01000061 EMBL· GenBank· DDBJ | OOK24645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NNAF01000055 EMBL· GenBank· DDBJ | OZO77242.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP063369 EMBL· GenBank· DDBJ | QOY32304.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QOGZ01000045 EMBL· GenBank· DDBJ | RDA33466.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SCIU01000045 EMBL· GenBank· DDBJ | RXB26096.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGDD01000002 EMBL· GenBank· DDBJ | STJ55129.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGED01000010 EMBL· GenBank· DDBJ | STM07662.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWVU01000001 EMBL· GenBank· DDBJ | VCW57261.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CABWJN010000003 EMBL· GenBank· DDBJ | VWN08803.1 EMBL· GenBank· DDBJ | Genomic DNA |