A0A024L2W8 · A0A024L2W8_ECOLX

  • Protein
    Gamma-aminobutyraldehyde dehydrogenase
  • Gene
    patD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.

Miscellaneous

4-aminobutanal can spontaneously cyclize to 1-pyrroline, and 5-aminopentanal to 1-piperideine.

Catalytic activity

Pathway

Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1.
Amino-acid degradation.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site146-148NAD+ (UniProtKB | ChEBI)
Binding site172-175NAD+ (UniProtKB | ChEBI)
Binding site209NAD+ (UniProtKB | ChEBI)
Binding site225-228NAD+ (UniProtKB | ChEBI)
Active site246
Active site280Nucleophile
Binding site280NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionaminobutyraldehyde dehydrogenase (NAD+) activity
Molecular FunctionNAD binding
Biological ProcessL-lysine catabolic process
Biological Processputrescine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Gamma-aminobutyraldehyde dehydrogenase
  • EC number
  • Short names
    ABALDH
  • Alternative names
    • 1-pyrroline dehydrogenase
    • 4-aminobutanal dehydrogenase
    • 5-aminopentanal dehydrogenase
      (EC:1.2.1.-
      ) . EC:1.2.1.- (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      patD
    • Synonyms
      prr
      , ydcW
    • ORF names
      ACU57_18205
      , BANRA_04102
      , BGZ_02389
      , BMT91_22725
      , C3F40_04375
      , CG704_19495
      , DTL43_23645
      , E4K51_23520
      , E6D34_22080
      , EIZ93_16845
      , EPS97_18655
      , FOI11_005915
      , FOI11_12885
      , G3V95_14585
      , GNW61_13465
      , GP944_19045
      , GP965_06500
      , GP979_08320
      , GQE86_18740
      , GRW05_21135
      , GRW24_17265
      , HMV95_17575
      , IH772_11260
      , J0541_003991
      , NCTC9045_03048
      , NCTC9962_05282
      , P6223_003238

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 1409
    • AW1.3
    • 2.3-R4
    • WW601
    • Escherichia coli
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    A0A024L2W8
  • Secondary accessions
    • A0A236PRF1

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-470Aldehyde dehydrogenase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    474
  • Mass (Da)
    50,860
  • Last updated
    2014-07-09 v1
  • MD5 Checksum
    A5910205E128DA53CCBD48DD02F8A97B
MQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVINILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVSKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP026399
EMBL· GenBank· DDBJ
AUY01109.1
EMBL· GenBank· DDBJ
Genomic DNA
AASEBA010000058
EMBL· GenBank· DDBJ
EFC9751896.1
EMBL· GenBank· DDBJ
Genomic DNA
AASWOY010000030
EMBL· GenBank· DDBJ
EFH6649744.1
EMBL· GenBank· DDBJ
Genomic DNA
ABLFQU030000031
EMBL· GenBank· DDBJ
EMM0026614.1
EMBL· GenBank· DDBJ
Genomic DNA
DABHXT010000030
EMBL· GenBank· DDBJ
HAJ5960048.1
EMBL· GenBank· DDBJ
Genomic DNA
DADUEU010000029
EMBL· GenBank· DDBJ
HBB1575009.1
EMBL· GenBank· DDBJ
Genomic DNA
LDYI01000120
EMBL· GenBank· DDBJ
KPO09259.1
EMBL· GenBank· DDBJ
Genomic DNA
JACGTG010000001
EMBL· GenBank· DDBJ
MBA6240873.1
EMBL· GenBank· DDBJ
Genomic DNA
JACZOI010000027
EMBL· GenBank· DDBJ
MBE0977861.1
EMBL· GenBank· DDBJ
Genomic DNA
RYCF01000062
EMBL· GenBank· DDBJ
MQK25956.1
EMBL· GenBank· DDBJ
Genomic DNA
SQQU01000050
EMBL· GenBank· DDBJ
MQS33062.1
EMBL· GenBank· DDBJ
Genomic DNA
WSXK01000059
EMBL· GenBank· DDBJ
MWF97071.1
EMBL· GenBank· DDBJ
Genomic DNA
WTQQ01000079
EMBL· GenBank· DDBJ
MWR88318.1
EMBL· GenBank· DDBJ
Genomic DNA
WTRC01000053
EMBL· GenBank· DDBJ
MWT20578.1
EMBL· GenBank· DDBJ
Genomic DNA
WTRX01000036
EMBL· GenBank· DDBJ
MWU32818.1
EMBL· GenBank· DDBJ
Genomic DNA
WUIY01000200
EMBL· GenBank· DDBJ
MXI76711.1
EMBL· GenBank· DDBJ
Genomic DNA
WUIG01000421
EMBL· GenBank· DDBJ
MXJ10201.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAGYI010000021
EMBL· GenBank· DDBJ
NEM86710.1
EMBL· GenBank· DDBJ
Genomic DNA
MPAF01000061
EMBL· GenBank· DDBJ
OOK24645.1
EMBL· GenBank· DDBJ
Genomic DNA
NNAF01000055
EMBL· GenBank· DDBJ
OZO77242.1
EMBL· GenBank· DDBJ
Genomic DNA
CP063369
EMBL· GenBank· DDBJ
QOY32304.1
EMBL· GenBank· DDBJ
Genomic DNA
QOGZ01000045
EMBL· GenBank· DDBJ
RDA33466.1
EMBL· GenBank· DDBJ
Genomic DNA
SCIU01000045
EMBL· GenBank· DDBJ
RXB26096.1
EMBL· GenBank· DDBJ
Genomic DNA
UGDD01000002
EMBL· GenBank· DDBJ
STJ55129.1
EMBL· GenBank· DDBJ
Genomic DNA
UGED01000010
EMBL· GenBank· DDBJ
STM07662.1
EMBL· GenBank· DDBJ
Genomic DNA
UWVU01000001
EMBL· GenBank· DDBJ
VCW57261.1
EMBL· GenBank· DDBJ
Genomic DNA
CABWJN010000003
EMBL· GenBank· DDBJ
VWN08803.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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