A0A024KZ56 · A0A024KZ56_ECOLX
- ProteinPimeloyl-[acyl-carrier protein] methyl ester esterase
- GenebioH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids256 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
Catalytic activity
- 6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + methanol + H+
Pathway
Cofactor biosynthesis; biotin biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 22 | substrate | ||||
Sequence: W | ||||||
Active site | 82 | Nucleophile | ||||
Sequence: S | ||||||
Binding site | 82-83 | substrate | ||||
Sequence: SL | ||||||
Binding site | 143-147 | substrate | ||||
Sequence: FLALQ | ||||||
Active site | 207 | |||||
Sequence: D | ||||||
Active site | 235 | |||||
Sequence: H | ||||||
Binding site | 235 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | pimelyl-[acyl-carrier protein] methyl ester esterase activity | |
Biological Process | biotin biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePimeloyl-[acyl-carrier protein] methyl ester esterase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionA0A024KZ56
- Secondary accessions
Proteomes
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-242 | AB hydrolase-1 | ||||
Sequence: HLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFISHP |
Sequence similarities
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length256
- Mass (Da)28,505
- Last updated2014-07-09 v1
- Checksum931226F241BBCBF3
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AASHPR010000013 EMBL· GenBank· DDBJ | EFC3524768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASURL010000030 EMBL· GenBank· DDBJ | EFH0365893.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASWOY010000015 EMBL· GenBank· DDBJ | EFH6648805.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ABLFQU030000002 EMBL· GenBank· DDBJ | EMM0023748.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABHXT010000008 EMBL· GenBank· DDBJ | HAJ5958220.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DADUEU010000011 EMBL· GenBank· DDBJ | HBB1573259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACGTG010000001 EMBL· GenBank· DDBJ | MBA6239287.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACZOI010000018 EMBL· GenBank· DDBJ | MBE0977374.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SQQU01000011 EMBL· GenBank· DDBJ | MQS30537.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WUIY01000187 EMBL· GenBank· DDBJ | MXI76617.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAGYI010000007 EMBL· GenBank· DDBJ | NEM85089.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP063369 EMBL· GenBank· DDBJ | QOY30419.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP070393 EMBL· GenBank· DDBJ | QRZ97151.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGDD01000002 EMBL· GenBank· DDBJ | STJ52635.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGDC01000003 EMBL· GenBank· DDBJ | STJ78083.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWVU01000001 EMBL· GenBank· DDBJ | VCW53161.1 EMBL· GenBank· DDBJ | Genomic DNA |