A0A023IRL2 · A0A023IRL2_9DIPT

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • COR_PUL_01
    • COR_PUL_02
    • FRA_PUL_04
    • FRA_PULI_01
    • FRA_PULT_01
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Chironomoidea > Ceratopogonidae > Ceratopogoninae > Culicoides > Culicoides

Accessions

  • Primary accession
    A0A023IRL2

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane46-72Helical
Transmembrane84-111Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_501089832225-145Cytochrome c oxidase subunit 1

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-145Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    145
  • Mass (Da)
    15,694
  • Last updated
    2014-07-09 v1
  • Checksum
    2167478A18B69D4B
MSFWMLPPSLTLLLLSSLVENGAGTGWTVYPPLSANISHAGASVDLAIFSLHLAGISSILGAVNFITTIINMRSNGISFDRMPLFVWSVLITAILLLLSLPVLAGAITMLLTDRNINTSFFDPAGGGDPILYQHLFWFFGHPEVY

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue145

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF591610
EMBL· GenBank· DDBJ
AHA12339.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591611
EMBL· GenBank· DDBJ
AHA12340.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591631
EMBL· GenBank· DDBJ
AHA12360.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591632
EMBL· GenBank· DDBJ
AHA12361.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591633
EMBL· GenBank· DDBJ
AHA12362.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591638
EMBL· GenBank· DDBJ
AHA12367.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591639
EMBL· GenBank· DDBJ
AHA12368.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591645
EMBL· GenBank· DDBJ
AHA12374.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591649
EMBL· GenBank· DDBJ
AHA12378.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591650
EMBL· GenBank· DDBJ
AHA12379.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591651
EMBL· GenBank· DDBJ
AHA12380.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591653
EMBL· GenBank· DDBJ
AHA12382.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591654
EMBL· GenBank· DDBJ
AHA12383.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591655
EMBL· GenBank· DDBJ
AHA12384.1
EMBL· GenBank· DDBJ
Genomic DNA
KF591656
EMBL· GenBank· DDBJ
AHA12385.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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