A0A023INR3 · A0A023INR3_GAMBA
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids184 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Peracarida > Amphipoda > Senticaudata > Gammarida > Gammaridira > Gammaroidea > Gammaridae > Gammarus
Accessions
- Primary accessionA0A023INR3
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 27-50 | Helical | ||||
Sequence: AHAFVMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 71-93 | Helical | ||||
Sequence: LLPPSLTLLLMSGLIESGVGTGW | ||||||
Transmembrane | 113-138 | Helical | ||||
Sequence: AIFSLHLAGASSILGAINFISTIINM | ||||||
Transmembrane | 150-177 | Helical | ||||
Sequence: LFVWSVFITAILLLLSLPVLAGAITMLL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-184 | Cytochrome oxidase subunit I profile | ||||
Sequence: SVIIRSELSTPGNLIGDDQLYNVMVTAHAFVMIFFMVMPIMIGGFGNWLVPLMLGSPDMAFPRMNNMSFWLLPPSLTLLLMSGLIESGVGTGWTVYPPLAGVTSHSGGAVDMAIFSLHLAGASSILGAINFISTIINMRSPGMPMDQMPLFVWSVFITAILLLLSLPVLAGAITMLLTDRNLNT |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length184
- Mass (Da)19,761
- Last updated2014-07-09 v1
- Checksum1F4D1FC06071D1BF
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: S | ||||||
Non-terminal residue | 184 | |||||
Sequence: T |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KF053224 EMBL· GenBank· DDBJ | AGX00088.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF053225 EMBL· GenBank· DDBJ | AGX00089.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF053231 EMBL· GenBank· DDBJ | AGX00095.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF053260 EMBL· GenBank· DDBJ | AGX00124.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF053261 EMBL· GenBank· DDBJ | AGX00125.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF053262 EMBL· GenBank· DDBJ | AGX00126.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF053263 EMBL· GenBank· DDBJ | AGX00127.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056316 EMBL· GenBank· DDBJ | ALN42449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056319 EMBL· GenBank· DDBJ | ALN42452.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056320 EMBL· GenBank· DDBJ | ALN42453.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056321 EMBL· GenBank· DDBJ | ALN42454.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056323 EMBL· GenBank· DDBJ | ALN42456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056324 EMBL· GenBank· DDBJ | ALN42457.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056325 EMBL· GenBank· DDBJ | ALN42458.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056326 EMBL· GenBank· DDBJ | ALN42459.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056327 EMBL· GenBank· DDBJ | ALN42460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056328 EMBL· GenBank· DDBJ | ALN42461.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056334 EMBL· GenBank· DDBJ | ALN42467.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056378 EMBL· GenBank· DDBJ | ALN42511.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056379 EMBL· GenBank· DDBJ | ALN42512.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056380 EMBL· GenBank· DDBJ | ALN42513.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056381 EMBL· GenBank· DDBJ | ALN42514.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056401 EMBL· GenBank· DDBJ | ALN42534.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056402 EMBL· GenBank· DDBJ | ALN42535.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056403 EMBL· GenBank· DDBJ | ALN42536.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056404 EMBL· GenBank· DDBJ | ALN42537.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056405 EMBL· GenBank· DDBJ | ALN42538.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056406 EMBL· GenBank· DDBJ | ALN42539.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056407 EMBL· GenBank· DDBJ | ALN42540.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056408 EMBL· GenBank· DDBJ | ALN42541.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056409 EMBL· GenBank· DDBJ | ALN42542.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056410 EMBL· GenBank· DDBJ | ALN42543.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056411 EMBL· GenBank· DDBJ | ALN42544.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056436 EMBL· GenBank· DDBJ | ALN42569.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056437 EMBL· GenBank· DDBJ | ALN42570.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056438 EMBL· GenBank· DDBJ | ALN42571.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056440 EMBL· GenBank· DDBJ | ALN42573.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056441 EMBL· GenBank· DDBJ | ALN42574.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056447 EMBL· GenBank· DDBJ | ALN42580.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056461 EMBL· GenBank· DDBJ | ALN42594.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056462 EMBL· GenBank· DDBJ | ALN42595.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU056463 EMBL· GenBank· DDBJ | ALN42596.1 EMBL· GenBank· DDBJ | Genomic DNA |