A0A023INR3 · A0A023INR3_GAMBA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • PL13-1
    • PL13-4
    • RO52-10
    • RO52-12
    • RO52-18
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Peracarida > Amphipoda > Senticaudata > Gammarida > Gammaridira > Gammaroidea > Gammaridae > Gammarus

Accessions

  • Primary accession
    A0A023INR3

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane27-50Helical
Transmembrane71-93Helical
Transmembrane113-138Helical
Transmembrane150-177Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-184Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    184
  • Mass (Da)
    19,761
  • Last updated
    2014-07-09 v1
  • Checksum
    1F4D1FC06071D1BF
SVIIRSELSTPGNLIGDDQLYNVMVTAHAFVMIFFMVMPIMIGGFGNWLVPLMLGSPDMAFPRMNNMSFWLLPPSLTLLLMSGLIESGVGTGWTVYPPLAGVTSHSGGAVDMAIFSLHLAGASSILGAINFISTIINMRSPGMPMDQMPLFVWSVFITAILLLLSLPVLAGAITMLLTDRNLNT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue184

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF053224
EMBL· GenBank· DDBJ
AGX00088.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053225
EMBL· GenBank· DDBJ
AGX00089.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053231
EMBL· GenBank· DDBJ
AGX00095.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053260
EMBL· GenBank· DDBJ
AGX00124.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053261
EMBL· GenBank· DDBJ
AGX00125.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053262
EMBL· GenBank· DDBJ
AGX00126.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053263
EMBL· GenBank· DDBJ
AGX00127.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056316
EMBL· GenBank· DDBJ
ALN42449.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056319
EMBL· GenBank· DDBJ
ALN42452.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056320
EMBL· GenBank· DDBJ
ALN42453.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056321
EMBL· GenBank· DDBJ
ALN42454.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056323
EMBL· GenBank· DDBJ
ALN42456.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056324
EMBL· GenBank· DDBJ
ALN42457.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056325
EMBL· GenBank· DDBJ
ALN42458.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056326
EMBL· GenBank· DDBJ
ALN42459.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056327
EMBL· GenBank· DDBJ
ALN42460.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056328
EMBL· GenBank· DDBJ
ALN42461.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056334
EMBL· GenBank· DDBJ
ALN42467.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056378
EMBL· GenBank· DDBJ
ALN42511.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056379
EMBL· GenBank· DDBJ
ALN42512.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056380
EMBL· GenBank· DDBJ
ALN42513.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056381
EMBL· GenBank· DDBJ
ALN42514.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056401
EMBL· GenBank· DDBJ
ALN42534.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056402
EMBL· GenBank· DDBJ
ALN42535.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056403
EMBL· GenBank· DDBJ
ALN42536.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056404
EMBL· GenBank· DDBJ
ALN42537.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056405
EMBL· GenBank· DDBJ
ALN42538.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056406
EMBL· GenBank· DDBJ
ALN42539.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056407
EMBL· GenBank· DDBJ
ALN42540.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056408
EMBL· GenBank· DDBJ
ALN42541.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056409
EMBL· GenBank· DDBJ
ALN42542.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056410
EMBL· GenBank· DDBJ
ALN42543.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056411
EMBL· GenBank· DDBJ
ALN42544.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056436
EMBL· GenBank· DDBJ
ALN42569.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056437
EMBL· GenBank· DDBJ
ALN42570.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056438
EMBL· GenBank· DDBJ
ALN42571.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056440
EMBL· GenBank· DDBJ
ALN42573.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056441
EMBL· GenBank· DDBJ
ALN42574.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056447
EMBL· GenBank· DDBJ
ALN42580.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056461
EMBL· GenBank· DDBJ
ALN42594.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056462
EMBL· GenBank· DDBJ
ALN42595.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056463
EMBL· GenBank· DDBJ
ALN42596.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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