A0A023INP2 · A0A023INP2_GAMBA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • PL12-1
    • PL12-2
    • RO07-12
    • RO07-13
    • RO07-15
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Peracarida > Amphipoda > Senticaudata > Gammarida > Gammaridira > Gammaroidea > Gammaridae > Gammarus

Accessions

  • Primary accession
    A0A023INP2

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-50Helical
Transmembrane71-93Helical
Transmembrane113-138Helical
Transmembrane150-177Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-184Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    184
  • Mass (Da)
    19,715
  • Last updated
    2014-07-09 v1
  • Checksum
    EB4BBB829A1E69E0
SVIIRSELSAPGNLLGDDQLYNVVVTAHAFVMIFFMVMPSMLGGFGNWLVPLMLGSPDMAFPRMNNMSFWLLPPSLTLLLMSGLVESGVGTGWTVYPPLAGVTSHSGGAVDLAIFSLHLAGMSSILGAINFISTIINMRSPGMPMDQMPLFVWSIFITAILLLLSLPVLAGAITMLLTDRNLNT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue184

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF053226
EMBL· GenBank· DDBJ
AGX00090.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053227
EMBL· GenBank· DDBJ
AGX00091.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053239
EMBL· GenBank· DDBJ
AGX00103.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053240
EMBL· GenBank· DDBJ
AGX00104.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053241
EMBL· GenBank· DDBJ
AGX00105.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053242
EMBL· GenBank· DDBJ
AGX00106.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053243
EMBL· GenBank· DDBJ
AGX00107.1
EMBL· GenBank· DDBJ
Genomic DNA
KF053244
EMBL· GenBank· DDBJ
AGX00108.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056376
EMBL· GenBank· DDBJ
ALN42509.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056377
EMBL· GenBank· DDBJ
ALN42510.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056395
EMBL· GenBank· DDBJ
ALN42528.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056396
EMBL· GenBank· DDBJ
ALN42529.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056397
EMBL· GenBank· DDBJ
ALN42530.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056398
EMBL· GenBank· DDBJ
ALN42531.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056399
EMBL· GenBank· DDBJ
ALN42532.1
EMBL· GenBank· DDBJ
Genomic DNA
KU056400
EMBL· GenBank· DDBJ
ALN42533.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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