A0A023IKK2 · A0A023IKK2_RAT

  • Protein
    MHC class II beta chain
  • Gene
    RT1-Db2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentlate endosome membrane
Cellular Componentlysosomal membrane
Cellular ComponentMHC class II protein complex
Molecular FunctionMHC class II protein complex binding
Molecular Functionpeptide antigen binding
Biological Processadaptive immune response
Biological Processantigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Processpeptide antigen assembly with MHC class II protein complex
Biological Processpositive regulation of immune response
Biological Processpositive regulation of T cell activation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Submitted names
    • MHC class II beta chain
    • RT1 class II, locus Db2
    • RT1-Db2

Gene names

    • Name
      RT1-Db2
    • Synonyms
      Db2

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Brown Norway
    • DA
    • DA.1F
    • DA.1H
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A023IKK2
  • Secondary accessions
    • A0A0G2JZX8
    • D3ZT06

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane227-249Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-28
ChainPRO_501400851429-287

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain125-215Ig-like
Region257-287Disordered
Compositional bias262-287Polar residues

Sequence similarities

Belongs to the MHC class II family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    287
  • Mass (Da)
    32,180
  • Last updated
    2014-07-09 v1
  • MD5 Checksum
    45CC7C1B0D34446E4F1CCF212D759ABC
MVCLWLPRDPCVAAVVLSLLMLSPPVALVRDPRPRFLEQLKAECHYVKGREHVWSVTRFIYNQEEFARFDSVFGKFLAVTELGRPIAEYLNTQKDMLDNYRASVDRCRNNYDLVDIFMSNLKAKPKVTVYPSKTQPLEYHNLLVCSVSDFYPGTIEIRWFRNGEEEKTGVVSTDLISNGDWTYQTLVMLETVPQGGEVYTCQVEHPSLTSPVRVEWRARSTSAQNKMLSGAMGMALGLFILAVGLFIYLRNLRAGSVSHGAGEGAESSTSRLTGSRSECHTGPALSV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8J8YBX6A0A8J8YBX6_RATRT1-Db2260

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias262-287Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC222923
EMBL· GenBank· DDBJ
AGV39020.1
EMBL· GenBank· DDBJ
mRNA
KC222924
EMBL· GenBank· DDBJ
AGV39021.1
EMBL· GenBank· DDBJ
mRNA
KC222926
EMBL· GenBank· DDBJ
AGV39023.1
EMBL· GenBank· DDBJ
mRNA
KP012532
EMBL· GenBank· DDBJ
AKO62641.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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