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A0A023I1S3 · A0A023I1S3_9APIC

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    coxI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      coxI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Piroplasmida > Theileriidae > Theileria

Accessions

  • Primary accession
    A0A023I1S3

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-43Helical
Transmembrane64-89Helical
Transmembrane121-139Helical
Transmembrane151-168Helical
Transmembrane180-201Helical
Transmembrane213-236Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-259Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    259
  • Mass (Da)
    28,240
  • Last updated
    2014-07-09 v1
  • MD5 Checksum
    984A610DC43E9EA56BFECDC2D58D3F68
GSGTGWTLYPPLSTSLSNVGIDFIIFGLLAAGIASTLSSVNFITTFTSIKTIGFVIDRISPVAWSIVLTSFLLLLSLPVVTAVFLMVFLDRHYNTMFFESSNSGDPVLYQHLFWFFGHPEVYIMILPGFGIISLLLSTYTTKEMFGNQTMILAMGSIALLGCLVWGHHMYTSGLEADTRGYFTTVTILIALPTGNKIFNWVTTLQCVESIRSLGLVLFAVLFIVNFVIGGTTGVILGNAGVDVALHDTVYVVGHFHFVL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue259

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC961494
EMBL· GenBank· DDBJ
AGS32385.1
EMBL· GenBank· DDBJ
Genomic DNA
KC961495
EMBL· GenBank· DDBJ
AGS32386.1
EMBL· GenBank· DDBJ
Genomic DNA
KC961498
EMBL· GenBank· DDBJ
AGS32389.1
EMBL· GenBank· DDBJ
Genomic DNA
KC961500
EMBL· GenBank· DDBJ
AGS32391.1
EMBL· GenBank· DDBJ
Genomic DNA
KC961505
EMBL· GenBank· DDBJ
AGS32396.1
EMBL· GenBank· DDBJ
Genomic DNA
KC961508
EMBL· GenBank· DDBJ
AGS32399.1
EMBL· GenBank· DDBJ
Genomic DNA
KC961509
EMBL· GenBank· DDBJ
AGS32400.1
EMBL· GenBank· DDBJ
Genomic DNA
KC961515
EMBL· GenBank· DDBJ
AGS32406.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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