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A0A023HMX0 · A0A023HMX0_CYPCA

Function

function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentmembrane attack complex
Cellular Componentother organism cell membrane
Biological Processcomplement activation, alternative pathway
Biological Processcomplement activation, classical pathway
Biological Processkilling of cells of another organism

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Complement component C9

Organism names

Accessions

  • Primary accession
    A0A023HMX0

Subcellular Location

Secreted
Target cell membrane
; Multi-pass membrane protein

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_500152230920-674Complement component C9
Disulfide bond103↔115
Disulfide bond110↔128

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain142-585MACPF
Region248-345Disordered
Compositional bias325-345Polar residues

Sequence similarities

Belongs to the complement C6/C7/C8/C9 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    674
  • Mass (Da)
    73,189
  • Last updated
    2014-07-09 v1
  • MD5 Checksum
    72E8FF320BC9FB828D72BEC1D6C200D2
MKALAALCVTICILYQVNGKSITEHMHGSRREVRQINDPGSIDCKMSAWSQWTSCDPCTNRTHRSRSIEVFGQFKGYRCIDPIGERKPCKPSTKCQMDPPPVCKSSQWRCASGICINKNLRCNGDYDCGEPDTSDEDECDIIRTPCGKTAVFESDIAIQAGYGINILGSGPRMNPFNNRFYNGQCNRIREPSTLEYNRLPWNVGVLSYETKVEESSSKEMYEDIHTLIKEISRESSTSYEVGLNFKFTPTEPSSSGSGEAGSAGGGGEVAGSSGGGEAASPDEGGAPEGPGEGGAPEGPGEGGAPEGPGQDGEPQGPGEGGDTEVSGAGQNNSPGLGFSASGGFDTKQSTTNIIKQLSEITVTKRKTFMRVKGRVELATYRMRQRGMEVSSTFLDDVDALPTTYEKGQYFAFLEDYGTHFTKNGKSGGEYELVYIMNEDVLKLKKVTESTVKKCLELGLRGDFQLTQGLTGGGHFKPKNDCDTLTDKPTDDRDTRGVNDKVLIAVRGGSPAAAVAMKSQLTKDGILDYSQYVEWAKTISALPALIHSDPEPIYNAIPLDFPDAQPRRENLRRALDDYVAEYSVCKCQPCQNGGTVIQIDGECKCMCLPGTEGVACQIIEMELVKAKSFEQLGNWVCWSSWSLCSGGRRRRTRTCNTRGVPGGTCRGDTTREDYC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias325-345Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC935373
EMBL· GenBank· DDBJ
AGN31551.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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