A0A023GL55 · A0A023GL55_AMBTT
- ProteinFlavin-containing monooxygenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids541 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.
Catalytic activity
- (2E)-geranial + NADPH + O2 + H+ = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP+ + H2OThis reaction proceeds in the forward direction.
- octan-3-one + NADPH + O2 + H+ = pentyl propanoate + NADP+ + H2OThis reaction proceeds in the forward direction.
- octan-3-one + NADPH + O2 + H+ = ethyl hexanoate + NADP+ + H2OThis reaction proceeds in the forward direction.
- sulcatone + NADPH + O2 + H+ = 4-methylpent-3-en-1-yl acetate + NADP+ + H2OThis reaction proceeds in the forward direction.
- heptan-2-one + NADPH + O2 + H+ = pentyl acetate + NADP+ + H2OThis reaction proceeds in the forward direction.
- heptan-4-one + NADPH + O2 + H+ = propyl butanoate + NADP+ + H2OThis reaction proceeds in the forward direction.
- hexan-3-one + NADPH + O2 + H+ = propyl propanoate + NADP+ + H2OThis reaction proceeds in the forward direction.
- hexan-3-one + NADPH + O2 + H+ = ethyl butanoate + NADP+ + H2OThis reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | hypotaurine dehydrogenase activity | |
Molecular Function | N,N-dimethylaniline monooxygenase activity | |
Molecular Function | NADP binding | |
Molecular Function | NADPH oxidase H202-forming activity | |
Biological Process | lipid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFlavin-containing monooxygenase
- EC number
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Parasitiformes > Ixodida > Ixodoidea > Ixodidae > Amblyomminae > Amblyomma
Accessions
- Primary accessionA0A023GL55
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 514-534 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length541
- Mass (Da)61,544
- Last updated2014-06-11 v1
- Checksum165500E50F7EA1D2
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GBBM01000802 EMBL· GenBank· DDBJ | JAC34616.1 EMBL· GenBank· DDBJ | mRNA |