A0A023B3L3 · A0A023B3L3_GRENI

Function

function

Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
    EC:3.1.4.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Function5'-3' exonuclease activity
Molecular Function5'-flap endonuclease activity
Molecular Functionflap-structured DNA binding
Molecular Functionmetal ion binding
Molecular Functionphosphodiesterase I activity
Biological Processinterstrand cross-link repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fanconi-associated nuclease
  • EC number

Gene names

    • ORF names
      GNI_110860

Organism names

Accessions

  • Primary accession
    A0A023B3L3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_500151145920-1891Fanconi-associated nuclease

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region57-99Disordered
Compositional bias68-87Polar residues
Region140-179Disordered
Compositional bias144-168Pro residues
Region215-234Disordered
Region265-330Disordered
Compositional bias869-892Polar residues
Region869-950Disordered
Compositional bias964-991Polar residues
Region964-997Disordered
Region1080-1103Disordered
Compositional bias1081-1097Polar residues
Region1164-1203Disordered
Compositional bias1171-1186Basic residues
Region1216-1242Disordered
Region1261-1288Disordered
Compositional bias1263-1277Basic and acidic residues
Region1433-1556Disordered
Region1677-1698Disordered
Region1792-1814Disordered
Domain1853-1888VRR-NUC

Sequence similarities

Belongs to the FAN1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,891
  • Mass (Da)
    204,501
  • Last updated
    2014-06-11 v1
  • Checksum
    5B9DFE843E341E7A
MLVLLPLLLLCSHAVKIIAGCAMMKKQQAGEVCCLQWIPGIETVREEDSCGNEVRVEGMHFGGSKDGSQPKDGSQPKSGSGVTTAQLRGAPESAPRRKEVASSAFVSSVLKTGSNPAPLPWALGPYPFKSLKGGILLKKKIPPETTPAPEPTPTPKPGPTPEPTPTPGPVLKIGSEISSDEFARPADLDVWVEAPSAVGVPSAAPSVDVWVEAPSSSIEAGTPGPGSVDVWEGPGAPREVWVEAPSSAQAPSPRPGRSGEVWVEAPSSVRVPSPGRRPSPAPSEDVWVEAPSPNKASPSSSRPFPAPSGDVWVEAPSSSKGSASASGPLPSVDAGNEWMNDPYYLRFFEAPLREVYVRYEHLWTAGEHALLVAYTTELSRQDKLLFIKLMMRQVQNVYEVTELQDRYWRIMFWRREEDLTAETIEQDRQHVLRSIQHLVEHRFLDPWKPTGDAVHKEDVYALKSLALPTLKALVQTCPDGKEVLKRLKRKEDLVDWITARLHSKVTPPIDRLSRARSPLRFPHTVLMLAPIEYGSVRNPFTKLTFAETVWKRVNSDLCGGSGLEGVTRVLVNGVASAFFKRLHLLNNLFSSFMPGAGGGAPTASLSEKIEGLLTQALKPGVLEEISAVEYVRTSEADRCLGLIAHPRLFETRRDLELYEEALAVIDAVKNLSIRAADVGDAEAAATATAQVHDLVRTGARCLVNYLQTRGPPLEPLPKYCETLQLVRATYLTSEPLNDNNTRGQNTTMLTNNPTHGEVLSTTTAERLAHHVFRRFTPEYLYSVGLFELSGMLETLKKYELAAALQTLVIACQATRMNRGKVFLRLIIDCKVHLKLPDTALHWGWLALSEADTLEPGFILDIAKQVRQLETKQTPKSVSSKKRNKSSNLDVGPMTVPPTAGPPAAPTAAGLSPADHGSSPPDDLASVSGTPLAEGKPSPAPQQPSRAAAVGYAATTRAVNSGDENVLLFTPSSPDQSSSTSHSATSQSAHHGAGCHHGSYPVAGRGPYCEHVKYESRQAPIAAATVRNFAETTRGFKGIYGQLPLLNLSGPNLEAVLRIVELEKMIDFLIPTRVVWGVRQKGRTRTASSASTRGRRGGGSNPSVALESDIEEDIFAEERDAAKDTKSRFYLDGTLVGVEQFALHYFLQGGEQCILGVESTRYGDRRIPKPAAKRRSAAKRKPAAKRRAAAKRTSDNKRSATTTVGAGVLREVVELLSDEEKQPGAGPPSAMPPGAMPPGAMQPSVATMRRDSELASGLEMLDAKTRPGPDHDDEQVPNKQGPDQQSPDEEWCAYGGGAYDWVGCHCEGSVVREFAALLLFPLVFNARVCAANAEAFITDKQTASCDVGTLDFYETRRDSIQAYMAILRQVTDPHELAFLLTFCASQLFEVRLLSATWSLHTNHPDAFKPIVDPLAVQEALQKLTAGYVSAPVPPGGPAPSAPAPSAPAQGGGSRKPPVAGPNPATPAGTPLMSSAKPPGRGPSGHIPPHLAHMVLTAGRNDGARTNYTGHRGGASGLPPLMNTVGGVSGTPLLSPQLGGRMPKPSPMLRKTPNSKWETPSKQKMWLRKQAVTNERNLILGYDRGIALLPHENIATAINRRFESGLSYGLELSQVAAGIKIEGVIQLLLHLCKCYPYWSNGMADLILWRKLHPHSLDPNPYPFVSPHVSDFLQHKGLEGSGKQNRGNVKEEDASSWGPSPVLKTETGVKTGVKTGVKTGVRTGSEAPDQMGLKLSPAMTMLMLVYLDPECWNKTAVLERLSIDLDVVDLESWVSILNSFCPKKRVSISSALGSTTFSPSPLDPTVRDPTDGDPTVRDPPRLIDLSDLLSDAAALETLRYIDLRTRRFDFRNACTVFSEVKGPGDALSQKQRLWLYTLVQAGVVANVCEVKERQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias68-87Polar residues
Compositional bias144-168Pro residues
Compositional bias869-892Polar residues
Compositional bias964-991Polar residues
Compositional bias1081-1097Polar residues
Compositional bias1171-1186Basic residues
Compositional bias1263-1277Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AFNH02000829
EMBL· GenBank· DDBJ
EZG55576.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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