A0A023B3L3 · A0A023B3L3_GRENI
- ProteinFanconi-associated nuclease
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1891 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Catalytic activity
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | 5'-3' exonuclease activity | |
Molecular Function | 5'-flap endonuclease activity | |
Molecular Function | flap-structured DNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphodiesterase I activity | |
Biological Process | interstrand cross-link repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFanconi-associated nuclease
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Gregarinasina > Eugregarinorida > Gregarinidae > Gregarina
Accessions
- Primary accessionA0A023B3L3
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MLVLLPLLLLCSHAVKIIA | ||||||
Chain | PRO_5001511459 | 20-1891 | Fanconi-associated nuclease | |||
Sequence: GCAMMKKQQAGEVCCLQWIPGIETVREEDSCGNEVRVEGMHFGGSKDGSQPKDGSQPKSGSGVTTAQLRGAPESAPRRKEVASSAFVSSVLKTGSNPAPLPWALGPYPFKSLKGGILLKKKIPPETTPAPEPTPTPKPGPTPEPTPTPGPVLKIGSEISSDEFARPADLDVWVEAPSAVGVPSAAPSVDVWVEAPSSSIEAGTPGPGSVDVWEGPGAPREVWVEAPSSAQAPSPRPGRSGEVWVEAPSSVRVPSPGRRPSPAPSEDVWVEAPSPNKASPSSSRPFPAPSGDVWVEAPSSSKGSASASGPLPSVDAGNEWMNDPYYLRFFEAPLREVYVRYEHLWTAGEHALLVAYTTELSRQDKLLFIKLMMRQVQNVYEVTELQDRYWRIMFWRREEDLTAETIEQDRQHVLRSIQHLVEHRFLDPWKPTGDAVHKEDVYALKSLALPTLKALVQTCPDGKEVLKRLKRKEDLVDWITARLHSKVTPPIDRLSRARSPLRFPHTVLMLAPIEYGSVRNPFTKLTFAETVWKRVNSDLCGGSGLEGVTRVLVNGVASAFFKRLHLLNNLFSSFMPGAGGGAPTASLSEKIEGLLTQALKPGVLEEISAVEYVRTSEADRCLGLIAHPRLFETRRDLELYEEALAVIDAVKNLSIRAADVGDAEAAATATAQVHDLVRTGARCLVNYLQTRGPPLEPLPKYCETLQLVRATYLTSEPLNDNNTRGQNTTMLTNNPTHGEVLSTTTAERLAHHVFRRFTPEYLYSVGLFELSGMLETLKKYELAAALQTLVIACQATRMNRGKVFLRLIIDCKVHLKLPDTALHWGWLALSEADTLEPGFILDIAKQVRQLETKQTPKSVSSKKRNKSSNLDVGPMTVPPTAGPPAAPTAAGLSPADHGSSPPDDLASVSGTPLAEGKPSPAPQQPSRAAAVGYAATTRAVNSGDENVLLFTPSSPDQSSSTSHSATSQSAHHGAGCHHGSYPVAGRGPYCEHVKYESRQAPIAAATVRNFAETTRGFKGIYGQLPLLNLSGPNLEAVLRIVELEKMIDFLIPTRVVWGVRQKGRTRTASSASTRGRRGGGSNPSVALESDIEEDIFAEERDAAKDTKSRFYLDGTLVGVEQFALHYFLQGGEQCILGVESTRYGDRRIPKPAAKRRSAAKRKPAAKRRAAAKRTSDNKRSATTTVGAGVLREVVELLSDEEKQPGAGPPSAMPPGAMPPGAMQPSVATMRRDSELASGLEMLDAKTRPGPDHDDEQVPNKQGPDQQSPDEEWCAYGGGAYDWVGCHCEGSVVREFAALLLFPLVFNARVCAANAEAFITDKQTASCDVGTLDFYETRRDSIQAYMAILRQVTDPHELAFLLTFCASQLFEVRLLSATWSLHTNHPDAFKPIVDPLAVQEALQKLTAGYVSAPVPPGGPAPSAPAPSAPAQGGGSRKPPVAGPNPATPAGTPLMSSAKPPGRGPSGHIPPHLAHMVLTAGRNDGARTNYTGHRGGASGLPPLMNTVGGVSGTPLLSPQLGGRMPKPSPMLRKTPNSKWETPSKQKMWLRKQAVTNERNLILGYDRGIALLPHENIATAINRRFESGLSYGLELSQVAAGIKIEGVIQLLLHLCKCYPYWSNGMADLILWRKLHPHSLDPNPYPFVSPHVSDFLQHKGLEGSGKQNRGNVKEEDASSWGPSPVLKTETGVKTGVKTGVKTGVRTGSEAPDQMGLKLSPAMTMLMLVYLDPECWNKTAVLERLSIDLDVVDLESWVSILNSFCPKKRVSISSALGSTTFSPSPLDPTVRDPTDGDPTVRDPPRLIDLSDLLSDAAALETLRYIDLRTRRFDFRNACTVFSEVKGPGDALSQKQRLWLYTLVQAGVVANVCEVKERQ |
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 57-99 | Disordered | ||||
Sequence: EGMHFGGSKDGSQPKDGSQPKSGSGVTTAQLRGAPESAPRRKE | ||||||
Compositional bias | 68-87 | Polar residues | ||||
Sequence: SQPKDGSQPKSGSGVTTAQL | ||||||
Region | 140-179 | Disordered | ||||
Sequence: KIPPETTPAPEPTPTPKPGPTPEPTPTPGPVLKIGSEISS | ||||||
Compositional bias | 144-168 | Pro residues | ||||
Sequence: ETTPAPEPTPTPKPGPTPEPTPTPG | ||||||
Region | 215-234 | Disordered | ||||
Sequence: SSSIEAGTPGPGSVDVWEGP | ||||||
Region | 265-330 | Disordered | ||||
Sequence: APSSVRVPSPGRRPSPAPSEDVWVEAPSPNKASPSSSRPFPAPSGDVWVEAPSSSKGSASASGPLP | ||||||
Compositional bias | 869-892 | Polar residues | ||||
Sequence: ETKQTPKSVSSKKRNKSSNLDVGP | ||||||
Region | 869-950 | Disordered | ||||
Sequence: ETKQTPKSVSSKKRNKSSNLDVGPMTVPPTAGPPAAPTAAGLSPADHGSSPPDDLASVSGTPLAEGKPSPAPQQPSRAAAVG | ||||||
Compositional bias | 964-991 | Polar residues | ||||
Sequence: NVLLFTPSSPDQSSSTSHSATSQSAHHG | ||||||
Region | 964-997 | Disordered | ||||
Sequence: NVLLFTPSSPDQSSSTSHSATSQSAHHGAGCHHG | ||||||
Region | 1080-1103 | Disordered | ||||
Sequence: KGRTRTASSASTRGRRGGGSNPSV | ||||||
Compositional bias | 1081-1097 | Polar residues | ||||
Sequence: GRTRTASSASTRGRRGG | ||||||
Region | 1164-1203 | Disordered | ||||
Sequence: RRIPKPAAKRRSAAKRKPAAKRRAAAKRTSDNKRSATTTV | ||||||
Compositional bias | 1171-1186 | Basic residues | ||||
Sequence: AKRRSAAKRKPAAKRR | ||||||
Region | 1216-1242 | Disordered | ||||
Sequence: SDEEKQPGAGPPSAMPPGAMPPGAMQP | ||||||
Region | 1261-1288 | Disordered | ||||
Sequence: DAKTRPGPDHDDEQVPNKQGPDQQSPDE | ||||||
Compositional bias | 1263-1277 | Basic and acidic residues | ||||
Sequence: KTRPGPDHDDEQVPN | ||||||
Region | 1433-1556 | Disordered | ||||
Sequence: PGGPAPSAPAPSAPAQGGGSRKPPVAGPNPATPAGTPLMSSAKPPGRGPSGHIPPHLAHMVLTAGRNDGARTNYTGHRGGASGLPPLMNTVGGVSGTPLLSPQLGGRMPKPSPMLRKTPNSKWE | ||||||
Region | 1677-1698 | Disordered | ||||
Sequence: GSGKQNRGNVKEEDASSWGPSP | ||||||
Region | 1792-1814 | Disordered | ||||
Sequence: TTFSPSPLDPTVRDPTDGDPTVR | ||||||
Domain | 1853-1888 | VRR-NUC | ||||
Sequence: VFSEVKGPGDALSQKQRLWLYTLVQAGVVANVCEVK |
Sequence similarities
Belongs to the FAN1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,891
- Mass (Da)204,501
- Last updated2014-06-11 v1
- Checksum5B9DFE843E341E7A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 68-87 | Polar residues | ||||
Sequence: SQPKDGSQPKSGSGVTTAQL | ||||||
Compositional bias | 144-168 | Pro residues | ||||
Sequence: ETTPAPEPTPTPKPGPTPEPTPTPG | ||||||
Compositional bias | 869-892 | Polar residues | ||||
Sequence: ETKQTPKSVSSKKRNKSSNLDVGP | ||||||
Compositional bias | 964-991 | Polar residues | ||||
Sequence: NVLLFTPSSPDQSSSTSHSATSQSAHHG | ||||||
Compositional bias | 1081-1097 | Polar residues | ||||
Sequence: GRTRTASSASTRGRRGG | ||||||
Compositional bias | 1171-1186 | Basic residues | ||||
Sequence: AKRRSAAKRKPAAKRR | ||||||
Compositional bias | 1263-1277 | Basic and acidic residues | ||||
Sequence: KTRPGPDHDDEQVPN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AFNH02000829 EMBL· GenBank· DDBJ | EZG55576.1 EMBL· GenBank· DDBJ | Genomic DNA |