A0A022MIE0 · A0A022MIE0_9ACTN

  • Protein
    2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
  • Gene
    dapD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site176Mg2+ 1 (UniProtKB | ChEBI); ligand shared between trimeric partners
Binding site193Mg2+ 2 (UniProtKB | ChEBI); ligand shared between trimeric partners
Active site209Acyl-anhydride intermediate
Binding site211succinyl-CoA (UniProtKB | ChEBI)
Binding site226succinyl-CoA (UniProtKB | ChEBI)
Binding site229succinyl-CoA (UniProtKB | ChEBI)
Binding site252succinyl-CoA (UniProtKB | ChEBI)
Binding site267-268succinyl-CoA (UniProtKB | ChEBI)
Binding site275succinyl-CoA (UniProtKB | ChEBI)
Binding site287succinyl-CoA (UniProtKB | ChEBI)
Binding site300-303succinyl-CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
Molecular Functionmagnesium ion binding
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
  • EC number
  • Alternative names
    • Tetrahydrodipicolinate N-succinyltransferase
      (THDP succinyltransferase
      ; THP succinyltransferase
      )
    • Tetrahydropicolinate succinylase

Gene names

    • Name
      dapD
    • ORF names
      CF54_25400

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Tu 6176
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A022MIE0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotrimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain120-1602,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    328
  • Mass (Da)
    33,685
  • Last updated
    2014-06-11 v1
  • Checksum
    B6F82ADD4ECD16AA
MTETAPRTTGAVAAGLATIAADGTVLDTWFPAPELTAEPGPAGTERLSAERAAELLGAGATAATGPDTRRGVEVVAVRTVIASLDDKPLDAHDAYLRLHLLSHRLVKPHGVSLDGIFGHLANVAWTSLGPVAVDDVEKVRLNARAEGLHLQVTSIDKFPRMTDYVAPKGVRIADADRVRLGAHLAEGTTVMHEGFVNFNAGTLGTSMVEGRISAGVVVGDGSDIGGGASTMGTLSGGGNVIISIGERCLIGAEAGVGIALGDECVVEAGLYVTAGTRVSMPDGQIVKARELSGASNILFRRNSVTGAVEARPNNAVWGGLNDVLHSHN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JFJQ01000814
EMBL· GenBank· DDBJ
EYT80460.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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