A0A022MIE0 · A0A022MIE0_9ACTN
- Protein2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
- GenedapD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids328 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
Catalytic activity
- (S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2O = (S)-2-succinylamino-6-oxoheptanedioate + CoA
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 176 | Mg2+ 1 (UniProtKB | ChEBI); ligand shared between trimeric partners | |||
Binding site | 193 | Mg2+ 2 (UniProtKB | ChEBI); ligand shared between trimeric partners | |||
Active site | 209 | Acyl-anhydride intermediate | |||
Binding site | 211 | succinyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 226 | succinyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 229 | succinyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 252 | succinyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 267-268 | succinyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 275 | succinyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 287 | succinyl-CoA (UniProtKB | ChEBI) | |||
Binding site | 300-303 | succinyl-CoA (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | diaminopimelate biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionA0A022MIE0
Proteomes
Subcellular Location
Interaction
Subunit
Homotrimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 120-160 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle | |||
Sequence similarities
Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length328
- Mass (Da)33,685
- Last updated2014-06-11 v1
- ChecksumB6F82ADD4ECD16AA
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JFJQ01000814 EMBL· GenBank· DDBJ | EYT80460.1 EMBL· GenBank· DDBJ | Genomic DNA |