A0A022L1H3 · A0A022L1H3_9ACTN
- ProteinUvrABC system protein A
- GeneuvrA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1009 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | excinuclease repair complex | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | DNA binding | |
Molecular Function | excinuclease ABC activity | |
Molecular Function | zinc ion binding | |
Biological Process | nucleotide-excision repair | |
Biological Process | SOS response |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameUvrABC system protein A
- Short namesUvrA protein
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Dietziaceae > Dietzia
Accessions
- Primary accessionA0A022L1H3
Proteomes
Subcellular Location
Interaction
Subunit
Forms a heterotetramer with UvrB during the search for lesions.
Structure
Family & Domains
Features
Showing features for domain, zinc finger, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 618-947 | ABC transporter | ||||
Sequence: LNPEKVLHVRGARENNLKNVDVVFPGGVLCAVTGVSGSGKSTLVNDILATSLANQLNRARQVPGRHSRIDGVESFDKLVQVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYKQGRFSFNVKGGRCEACQGDGTLKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTIAEVLDMPIEEACEFFEPITSIHRYLKTLSQVGLGYVRLGQSAPTLSGGEAQRVKLAAELQKRSSGRTVYILDEPTTGLHFEDITKLLLVIQGLVDKGNTVIVIEHNLDVIKSADWVIDMGPEGGAGGGVVVAEGTPEQVATVPESHTGRFLA | ||||||
Zinc finger | 750-776 | C4-type | ||||
Sequence: CEACQGDGTLKIEMNFLPDVYVPCEVC | ||||||
Region | 956-1009 | Disordered | ||||
Sequence: EPAEGRRPGGKQAGRASAGTTATTKAATTKTVATKAPAKKAAAAKAARKARALR | ||||||
Compositional bias | 971-986 | Polar residues | ||||
Sequence: ASAGTTATTKAATTKT |
Sequence similarities
Belongs to the ABC transporter superfamily. UvrA family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,009
- Mass (Da)109,586
- Last updated2014-06-11 v1
- ChecksumD820709C7D3424D9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 971-986 | Polar residues | ||||
Sequence: ASAGTTATTKAATTKT |