A0A016XG18 · A0A016XG18_9BURK
- ProteinBeta-ketoacyl-[acyl-carrier-protein] synthase III
- GenefabH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids325 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
Catalytic activity
- malonyl-[ACP] + acetyl-CoA + H+ = 3-oxobutanoyl-[ACP] + CO2 + CoA
Pathway
Lipid metabolism; fatty acid biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 119 | |||||
Sequence: C | ||||||
Active site | 252 | |||||
Sequence: H | ||||||
Active site | 282 | |||||
Sequence: N |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] synthase activity | |
Molecular Function | beta-ketoacyl-acyl-carrier-protein synthase III activity | |
Biological Process | fatty acid biosynthetic process | |
Biological Process | secondary metabolite biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBeta-ketoacyl-[acyl-carrier-protein] synthase III
- EC number
- Short namesBeta-ketoacyl-ACP synthase III ; KAS III
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Hylemonella
Accessions
- Primary accessionA0A016XG18
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 113-190 | Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal | ||||
Sequence: FDVQAVCSGFIYALTVADSMIRAGAASKALVVGAEVFSRIIDFKDRTTCVLFGDGAGAVVLQASETPGILASDLKADG | ||||||
Domain | 236-324 | Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal | ||||
Sequence: LAKAGKTEADIDWLVPHQANIRIMMGAAKKLKLAPEKVVVTVDQHGNTSAASIPLALDHGVRQGQIKQGDTLLLEAVGGGLTWGAVLLT | ||||||
Region | 253-257 | ACP-binding | ||||
Sequence: QANIR |
Domain
The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.
Sequence similarities
Belongs to the thiolase-like superfamily. FabH family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length325
- Mass (Da)33,765
- Last updated2014-06-11 v1
- Checksum54E9E81A83AF0418