A0A015U647 · A0A015U647_BACFG

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

166450100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site217-224ATP (UniProtKB | ChEBI)
Binding site440Zn2+ (UniProtKB | ChEBI); catalytic
Active site441
Binding site444Zn2+ (UniProtKB | ChEBI); catalytic
Binding site515Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      hflB
    • Synonyms
      ftsH
    • ORF names
      M125_1063

Organism names

Accessions

  • Primary accession
    A0A015U647

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-23Helical
Transmembrane119-140Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

Type
IDPosition(s)Description
Domain209-349AAA+ ATPase
Coiled coil566-593
Region621-664Disordered
Compositional bias641-664Polar residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    664
  • Mass (Da)
    73,709
  • Last updated
    2014-06-11 v1
  • Checksum
    BE6DBFFD0AC23527
MPKFNLNWMYMIIALMLLGLYFANGSSSISKNISYDEFQQYVRDGYVSKVIGYDDNSVEIYIKPQYVGTVFKQDSTRVGRNPMITTEAPSRENLDNFLQKEKEETHFDGSVSYDKKKDYFSAILWNVLPIVFLIALWIFFMRRMGSGASGGAGGVFNVGKSKAQLFEKGGSIKVTFKDVAGLAEAKQEVEEIVEFLKEPQKYTDLGGKIPKGALLVGPPGTGKTLLAKAVAGEANVPFFSLAGSDFVEMFVGVGASRVRDLFKQAKEKAPCIVFIDEIDAVGRARGKNPAMGGNDERENTLNQLLTEMDGFGSNSGVIILAATNRVDVLDKALLRAGRFDRQIHVDLPDLNERKEVFGVHLRPIKIDDTVDVDLLARQTPGFSGADIANVCNEAALIAARHGKKFVGKQDFLDAVDRIIGGLEKKTKITTEAERRSIALHEAGHASISWLLEYANPLIKVTIVPRGRALGAAWYLPEERQITTKEQMLDEMCATLGGRAAEDLFIGRVSSGAANDLERVTKQAYGMIAYLGMSEKLPNLCYYNNDEYSFQRPYSEKTAELIDEEVKRMVNEQYERAKQILSEHKEQHNELAQLLIDKEVIFAEDVERIFGKRPWASRSEEIMAANNKQENAVHPADGEDVDTTTPQATESQEGNTQQESAASQN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias641-664Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JGDB01000021
EMBL· GenBank· DDBJ
EXY92284.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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