A0A014QBG8 · A0A014QBG8_9BURK

Function

function

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphomonoester.
    EC:3.1.26.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site26a divalent metal cation (UniProtKB | ChEBI)
Binding site27a divalent metal cation (UniProtKB | ChEBI)
Binding site118a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribonuclease H2 complex
Molecular Functionmanganese ion binding
Molecular FunctionRNA binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological ProcessDNA replication, removal of RNA primer
Biological Processmismatch repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease HII
  • EC number
  • Short names
    RNase HII

Gene names

    • Name
      rnhB
    • ORF names
      AX13_16520

Organism names

  • Taxonomic identifier
  • Strain
    • DA1877
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Comamonas

Accessions

  • Primary accession
    A0A014QBG8

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-209RNase H type-2

Sequence similarities

Belongs to the RNase HII family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    217
  • Mass (Da)
    23,117
  • Last updated
    2014-06-11 v1
  • Checksum
    5E86C732D043B260
MPSKKFSLPEQGSLPWHAPGLVAGVDEAGRGPLAGPVVAAAVILDDLHPIAGLADSKKLTALRREKLFDEIRAKALCFCIAEASVEEIDRLNILQATLLAMQRAVHGLRLKPALVQVDGNRLPVLEVQAEAIVKGDALVQAISAASILAKVHRDRWCEGFDREYPGYGFAAHKGYGTAAHLQALRGLGATPAHRRSFAPVAQVIHTFAARETAATTA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JBOK01000007
EMBL· GenBank· DDBJ
EXU80512.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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