A0A014Q6S5 · A0A014Q6S5_9BURK

Function

function

Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site253-phosphoshikimate (UniProtKB | ChEBI)
Binding site25phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site263-phosphoshikimate (UniProtKB | ChEBI)
Binding site303-phosphoshikimate (UniProtKB | ChEBI)
Binding site101phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site129phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site1783-phosphoshikimate (UniProtKB | ChEBI)
Binding site1793-phosphoshikimate (UniProtKB | ChEBI)
Binding site1803-phosphoshikimate (UniProtKB | ChEBI)
Binding site180phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site2083-phosphoshikimate (UniProtKB | ChEBI)
Active site331Proton acceptor
Binding site3313-phosphoshikimate (UniProtKB | ChEBI)
Binding site3583-phosphoshikimate (UniProtKB | ChEBI)
Binding site362phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site407phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site434phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site460-468ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-phosphoshikimate 1-carboxyvinyltransferase activity
Molecular FunctionATP binding
Molecular FunctionCMP kinase activity
Molecular FunctiondCMP kinase activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processpyrimidine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    3-phosphoshikimate 1-carboxyvinyltransferase
  • EC number
  • Alternative names
    • 5-enolpyruvylshikimate-3-phosphate synthase
      (EPSP synthase
      ; EPSPS
      )
  • Recommended name
    Cytidylate kinase
  • EC number
  • Short names
    CK
  • Alternative names
    • Cytidine monophosphate kinase
      (CMP kinase
      )

Gene names

    • Name
      aroA
    • Synonyms
      cmk
    • ORF names
      AX13_09220

Organism names

  • Taxonomic identifier
  • Strain
    • DA1877
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Comamonas

Accessions

  • Primary accession
    A0A014Q6S5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-442Enolpyruvate transferase
Domain456-666Cytidylate kinase

Sequence similarities

Belongs to the EPSP synthase family.
Belongs to the cytidylate kinase family. Type 1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    677
  • Mass (Da)
    72,340
  • Last updated
    2014-06-11 v1
  • Checksum
    18F92979745CF902
MYQTAFLDLPHLATASGSVQLPGSKSISNRVLLLAALSAGTTTIHDLLDSDDTRVMLAALRELGCQVTPAQVTPGQPVQITGIDGALPNNARAQLFLGNAGTAMRPLTAALAVLGGHFEMTGVPRMYERPIGDLVDALRQLGCHIDYLGNPGYPPLRIGQPNFSQLGDAPIAVRGDVSSQFLTALLMALPLLASDSDICIEVVGELISKPYIHITLELLSRFGITVRNEGWQRFVIPAGSRYQSPGDIHVEADASSASYFIALGAIATGAGGQNGIQVLGVGQDSIQGDIRFVEAAQAMGAQVTSGPNWLHITRGAWPLKAIDLDCNHIPDAAMTLASMALYADGTTTLRNIASWRVKETDRIAAMATELRKLGATVEEGADFLRITPPATAADWRAASIHTYDDHRVAMCFSLAAFNPAGLPVRIEDPKCVAKTFPDYFEAFFGVAQASRPTPVICIDGPTASGKGTIAGLVAERLGFALLDSGALYRITGLAASRAGIALTEDNAPAIADLIRRSHIGFTPDQRVLLDGEDISLAIRTEDASMNASRVAAFPAVREALLQVQRDFRRLPGLVGDGRDMGTVIFPDAPLKVYLTATAECRAERRYKQLISKGLSANMADLLADLQARDARDMNRAAAPLKPAEDALHLDNSEGTIEQAVQQILTWWEQRQPFAPRA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JBOK01000024
EMBL· GenBank· DDBJ
EXU78902.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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