A0A014NMB1 · A0A014NMB1_9GAMM

  • Protein
    5'/3'-nucleotidase SurE
  • Gene
    surE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 1 divalent metal cation per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site8a divalent metal cation (UniProtKB | ChEBI)
Binding site9a divalent metal cation (UniProtKB | ChEBI)
Binding site39a divalent metal cation (UniProtKB | ChEBI)
Binding site92a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3'-nucleotidase activity
Molecular Functionexopolyphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular FunctionXMP 5'-nucleosidase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5'/3'-nucleotidase SurE
  • EC number
  • Alternative names
    • Exopolyphosphatase
      (EC:3.6.1.11
      ) . EC:3.6.1.11 (UniProtKB | ENZYME | Rhea)
    • Nucleoside monophosphate phosphohydrolase

Gene names

    • Name
      surE
    • ORF names
      BG55_14620

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BT-MARDI
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae > Erwinia

Accessions

  • Primary accession
    A0A014NMB1

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-181Survival protein SurE-like phosphatase/nucleotidase

Sequence similarities

Belongs to the SurE nucleotidase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    253
  • Mass (Da)
    27,112
  • Last updated
    2014-06-11 v1
  • Checksum
    9D0AB41920B35CF1
MRILLSNDDGIHAPGIQVLAEALREFADVQVVAPDRNRSGASNSLTLETPLRTFRYPDGDIAVQQGTPTDCVWLGVNTLMTPKPDIVVSGINAGPNMGDDVIYSGTVAAAMEGRHLGLPALAVSLNGHQYYDTAAAVTCSILRALQHEPLHTGRILNINVPDLPLAELKGIRVTRCGSRHPSDRAIPQLDPRGNTFYWIGPPGEKLDAGPDTDFAAIDEGYVSVTALHVDLTAHAAQNVVADWLARVEVSGKW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JFHN01000053
EMBL· GenBank· DDBJ
EXU74945.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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