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A0A014MSQ8 · A0A014MSQ8_9BURK

  • Protein
    Phosphoribosylglycinamide formyltransferase
  • Gene
    purN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site12-14N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site69(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site94-97(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site111(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site113Proton donor
Site149Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • ORF names
      AX13_13440

Organism names

  • Taxonomic identifier
  • Strain
    • DA1877
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Comamonas

Accessions

  • Primary accession
    A0A014MSQ8

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-186Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    193
  • Mass (Da)
    20,827
  • Last updated
    2014-06-11 v1
  • MD5 Checksum
    A8D615FC42EC4A915AB02505E08DB7DF
MKNIVILISGGGSNMAAIVKAAKQQDWERRYGARVAAVVSNKADAKGLVFAREQGIATEVLDHRQFASREDFDAALAQRIDPYQPAVVVLAGFMRILTPGFVQHFAGRMVNIHPSLLPAFTGLHTHQRAIDAGCKFAGCTVHGVTAELDVGPILDQAVVPVLPDDTAETLAARVLTQEHIIYPRAVAALLQQR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JBOK01000004
EMBL· GenBank· DDBJ
EXU81119.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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