A0A014MLG5 · A0A014MLG5_9BURK

  • Protein
    UDP-2,3-diacylglucosamine hydrolase
  • Gene
    lpxH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 Mn2+ ions per subunit in a binuclear metal center.

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site24Mn2+ 1 (UniProtKB | ChEBI)
Binding site26Mn2+ 1 (UniProtKB | ChEBI)
Binding site55Mn2+ 2 (UniProtKB | ChEBI)
Binding site55Mn2+ 1 (UniProtKB | ChEBI)
Binding site95Mn2+ 2 (UniProtKB | ChEBI)
Binding site95-96substrate
Binding site130Mn2+ 2 (UniProtKB | ChEBI)
Binding site138substrate
Binding site176substrate
Binding site210Mn2+ 2 (UniProtKB | ChEBI)
Binding site210substrate
Binding site212Mn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextrinsic component of plasma membrane
Molecular Functionmanganese ion binding
Molecular FunctionUDP-2,3-diacylglucosamine hydrolase activity
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-2,3-diacylglucosamine hydrolase
  • EC number
  • Alternative names
    • UDP-2,3-diacylglucosamine diphosphatase

Gene names

    • Name
      lpxH
    • ORF names
      AX13_08530

Organism names

  • Taxonomic identifier
  • Strain
    • DA1877
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Comamonas

Accessions

  • Primary accession
    A0A014MLG5

Proteomes

Subcellular Location

Cell inner membrane
; Peripheral membrane protein

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-214Calcineurin-like phosphoesterase

Sequence similarities

Belongs to the LpxH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    267
  • Mass (Da)
    29,790
  • Last updated
    2014-06-11 v1
  • Checksum
    95A51F53E97D8133
MSTVLPAQELVAPALWHTVEFISDLHLDPAEPGTLDAWRRYLRSSRADAIFMLGDLFEVWVGDDTLDEPGSFEADAAASLQQAAAQRPLFFMVGNRDFLAGDAFLQRSGMTGLSDPTVLVLGERRILLSHGDALCLEDVDYQKFRALSRSAAWMQHTLGQPLAARRALGKAMRTESQLRKDSGAEYADVDLPATLQWMDATDTQWFIHGHTHRPADHALPADARGRPRNRIVLSDWHLDAHTHRAEVLRVNAQGWQRLPLETAVPRA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JBOK01000022
EMBL· GenBank· DDBJ
EXU78969.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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