A0A014LT85 · A0A014LT85_9ACTN

  • Protein
    Probable endonuclease 4
  • Gene
    nfo
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.
    EC:3.1.21.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 3 Zn2+ ions.

Features

Showing features for binding site.

129120406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site73Zn2+ 1 (UniProtKB | ChEBI)
Binding site113Zn2+ 1 (UniProtKB | ChEBI)
Binding site152Zn2+ 2 (UniProtKB | ChEBI)
Binding site152Zn2+ 1 (UniProtKB | ChEBI)
Binding site186Zn2+ 2 (UniProtKB | ChEBI)
Binding site189Zn2+ 3 (UniProtKB | ChEBI)
Binding site223Zn2+ 2 (UniProtKB | ChEBI)
Binding site236Zn2+ 3 (UniProtKB | ChEBI)
Binding site238Zn2+ 3 (UniProtKB | ChEBI)
Binding site268Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondeoxyribonuclease IV (phage-T4-induced) activity
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable endonuclease 4
  • EC number
  • Alternative names
    • Endodeoxyribonuclease IV
    • Endonuclease IV

Gene names

    • Name
      nfo
    • ORF names
      Z951_06990

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • PRh5
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A014LT85

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain26-285Xylose isomerase-like TIM barrel

Sequence similarities

Belongs to the AP endonuclease 2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    291
  • Mass (Da)
    30,629
  • Last updated
    2014-06-11 v1
  • MD5 Checksum
    DF43AD95786917F958FD5B51E3D8B8FA
MSTHRIRNPIGGHIRVAGGLATVGLAHAADIGAETVQVFVANPRGWATPVGTPAQDEAFRAGCAERSIPVYVHAPYLINFGSHTEATAERSVASLRHSLRRGREIGALGVVVHTGSATGGRPRATAIAQVRERVLPLLDELTRDDDPWLLLEPTAGQGTSLCALVEDLGPYFEALDRHPRLGVCLDTCHVFAAGHDLAAPGGVKQTLDELVAVAGEGRLRLIHANDSKDVVGAHKDRHANIGAGHIGAEPFRELFAHRATDGVPLVIETPGGTEGHAADVARLKELRAGVA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABQ01000007
EMBL· GenBank· DDBJ
EXU68919.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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