A0A014LAI6 · A0A014LAI6_9ACTN

  • Protein
    Urocanate hydratase
  • Gene
    hutU
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Note: Binds 1 NAD+ per subunit.

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site48-49NAD+ (UniProtKB | ChEBI)
Binding site126NAD+ (UniProtKB | ChEBI)
Binding site172-174NAD+ (UniProtKB | ChEBI)
Binding site192NAD+ (UniProtKB | ChEBI)
Binding site238-239NAD+ (UniProtKB | ChEBI)
Binding site259-263NAD+ (UniProtKB | ChEBI)
Binding site268-269NAD+ (UniProtKB | ChEBI)
Binding site317NAD+ (UniProtKB | ChEBI)
Active site405
Binding site487NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionurocanate hydratase activity
Biological ProcessL-histidine catabolic process to glutamate and formamide
Biological ProcessL-histidine catabolic process to glutamate and formate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urocanate hydratase
  • EC number
  • Short names
    Urocanase
  • Alternative names
    • Imidazolonepropionate hydrolase

Gene names

    • Name
      hutU
    • ORF names
      Z951_20035

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • PRh5
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A014LAI6

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-133Urocanase N-terminal
Domain136-343Urocanase Rossmann-like
Domain346-540Urocanase C-terminal

Sequence similarities

Belongs to the urocanase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    553
  • Mass (Da)
    59,991
  • Last updated
    2014-06-11 v1
  • Checksum
    1E017085655847CE
MTGPRPVRAPRGAELSARGWQQEAALRMLQNNLDPEVAEHPDKLVVYGGTGKAARDWRSFDAMVRTLRTLKQDETMLVQSGRPVGVMQTHEWAPRVLIANSNLVGDWANWEEFRRLEALGLTMYGQMTAGSWIYIGTQGILQGTYETFAAVAAKKFGGTLAGTITLTAGLGGMGGAQPLAVTMNDGVAICVDCDPRAIERRIDHRYLDVRADSLDHALQLATEARDARRPLSIGVLGNAAELIPQLLAMNAPIDIVTDQTSAHDPLSYLPVGVDFDEMASYAAEKPADFTQRARESMAKHVEAMVGFMDAGAEVFDYGNSIRGEAKLAGFERAFAFPGFVPAYIRPLFCEGKGPFRWAALSGDPKDIAATDKAILELFPENESLARWIKMAEERVHFQGLPARICWLGYGERDKAGERFNEMVADGTLAAPLAIGRDHLDCGSVASPYRETEAMLDGSDAIADWPLLNAMVNVASGASWVSIHHGGGVGMGRSIHAGQVTVADGTALAGEKIRRVLTNDPGMGVIRHVDAGYDRADEVADERDVRIPMRETDK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABQ01000027
EMBL· GenBank· DDBJ
EXU66426.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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