A0A014LAI6 · A0A014LAI6_9ACTN
- ProteinUrocanate hydratase
- GenehutU
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids553 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
Catalytic activity
- 4-imidazolone-5-propanoate = trans-urocanate + H2O
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 48-49 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GG | ||||||
Binding site | 126 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 172-174 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GMG | ||||||
Binding site | 192 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 238-239 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: NA | ||||||
Binding site | 259-263 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: QTSAH | ||||||
Binding site | 268-269 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: YL | ||||||
Binding site | 317 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Active site | 405 | |||||
Sequence: C | ||||||
Binding site | 487 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | urocanate hydratase activity | |
Biological Process | L-histidine catabolic process to glutamate and formamide | |
Biological Process | L-histidine catabolic process to glutamate and formate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUrocanate hydratase
- EC number
- Short namesUrocanase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionA0A014LAI6
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-133 | Urocanase N-terminal | ||||
Sequence: VRAPRGAELSARGWQQEAALRMLQNNLDPEVAEHPDKLVVYGGTGKAARDWRSFDAMVRTLRTLKQDETMLVQSGRPVGVMQTHEWAPRVLIANSNLVGDWANWEEFRRLEALGLTMYGQMTAGSWI | ||||||
Domain | 136-343 | Urocanase Rossmann-like | ||||
Sequence: GTQGILQGTYETFAAVAAKKFGGTLAGTITLTAGLGGMGGAQPLAVTMNDGVAICVDCDPRAIERRIDHRYLDVRADSLDHALQLATEARDARRPLSIGVLGNAAELIPQLLAMNAPIDIVTDQTSAHDPLSYLPVGVDFDEMASYAAEKPADFTQRARESMAKHVEAMVGFMDAGAEVFDYGNSIRGEAKLAGFERAFAFPGFVPAY | ||||||
Domain | 346-540 | Urocanase C-terminal | ||||
Sequence: PLFCEGKGPFRWAALSGDPKDIAATDKAILELFPENESLARWIKMAEERVHFQGLPARICWLGYGERDKAGERFNEMVADGTLAAPLAIGRDHLDCGSVASPYRETEAMLDGSDAIADWPLLNAMVNVASGASWVSIHHGGGVGMGRSIHAGQVTVADGTALAGEKIRRVLTNDPGMGVIRHVDAGYDRADEVAD |
Sequence similarities
Belongs to the urocanase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length553
- Mass (Da)59,991
- Last updated2014-06-11 v1
- Checksum1E017085655847CE
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JABQ01000027 EMBL· GenBank· DDBJ | EXU66426.1 EMBL· GenBank· DDBJ | Genomic DNA |