A0A014KT65 · A0A014KT65_MYCMC

Function

function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.
    EC:3.1.21.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 3 Zn2+ ions.

Features

Showing features for binding site.

128920406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site74Zn2+ 1 (UniProtKB | ChEBI)
Binding site115Zn2+ 1 (UniProtKB | ChEBI)
Binding site150Zn2+ 1 (UniProtKB | ChEBI)
Binding site150Zn2+ 2 (UniProtKB | ChEBI)
Binding site184Zn2+ 2 (UniProtKB | ChEBI)
Binding site187Zn2+ 3 (UniProtKB | ChEBI)
Binding site218Zn2+ 2 (UniProtKB | ChEBI)
Binding site231Zn2+ 3 (UniProtKB | ChEBI)
Binding site233Zn2+ 3 (UniProtKB | ChEBI)
Binding site263Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondeoxyribonuclease IV (phage-T4-induced) activity
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable endonuclease 4
  • EC number
  • Alternative names
    • Endodeoxyribonuclease IV
    • Endonuclease IV

Gene names

    • Name
      nfo
    • ORF names
      MMC_6650

Organism names

Accessions

  • Primary accession
    A0A014KT65

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain26-275Xylose isomerase-like TIM barrel

Sequence similarities

Belongs to the AP endonuclease 2 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    289
  • Mass (Da)
    33,116
  • Last updated
    2014-06-11 v1
  • Checksum
    12B9F12CC4BBA12E
MNKVLLGCHVSMNKQNNYLVGSVNEAISYKANTFMIFTGPPQSTLRTNTNHLYINQMHELMNSYKIDAKDLVVHAPYIINIANSVDQNKWKFAVDFLIQEIKRCEEIKIPTLVLHPGSYTTGNYKDSLNQIIKALDIVSNYQVNVKIALETMSGKGTEVCSKLEDFKYILDNVKNKDKVGVCLDTCHLHDAGYDLSKWDEFKEQMKQNFDLNKVLCIHLNDSKNMISSHKDRHANIGYGYVGFDTLVNVVFDKDFSNISKILETPYIDKNAPYKIEIEDLLNKTFTNRL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JFAE01000020
EMBL· GenBank· DDBJ
EXU60171.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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