A0A014KT65 · A0A014KT65_MYCMC
- ProteinProbable endonuclease 4
- Genenfo
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids289 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
Catalytic activity
Cofactor
Note: Binds 3 Zn2+ ions.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 74 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 115 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 150 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 150 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 184 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 187 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 218 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 231 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 233 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 263 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | deoxyribonuclease IV (phage-T4-induced) activity | |
Molecular Function | DNA binding | |
Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | phosphoric diester hydrolase activity | |
Molecular Function | zinc ion binding | |
Biological Process | base-excision repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable endonuclease 4
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Mycoplasmatota > Mollicutes > Mycoplasmataceae > Mycoplasma
Accessions
- Primary accessionA0A014KT65
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-275 | Xylose isomerase-like TIM barrel | ||||
Sequence: AISYKANTFMIFTGPPQSTLRTNTNHLYINQMHELMNSYKIDAKDLVVHAPYIINIANSVDQNKWKFAVDFLIQEIKRCEEIKIPTLVLHPGSYTTGNYKDSLNQIIKALDIVSNYQVNVKIALETMSGKGTEVCSKLEDFKYILDNVKNKDKVGVCLDTCHLHDAGYDLSKWDEFKEQMKQNFDLNKVLCIHLNDSKNMISSHKDRHANIGYGYVGFDTLVNVVFDKDFSNISKILETPYIDKNAPYKI |
Sequence similarities
Belongs to the AP endonuclease 2 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length289
- Mass (Da)33,116
- Last updated2014-06-11 v1
- Checksum12B9F12CC4BBA12E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JFAE01000020 EMBL· GenBank· DDBJ | EXU60171.1 EMBL· GenBank· DDBJ | Genomic DNA |