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A0A013T7A4 · A0A013T7A4_9GAMM

  • Protein
    Phosphoribosylformylglycinamidine synthase
  • Gene
    purL
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site304-315ATP (UniProtKB | ChEBI)
Binding site671ATP (UniProtKB | ChEBI)
Binding site672Mg2+ (UniProtKB | ChEBI)
Binding site711Mg2+ (UniProtKB | ChEBI)
Binding site715Mg2+ (UniProtKB | ChEBI)
Binding site878Mg2+ (UniProtKB | ChEBI)
Active site1118Nucleophile
Active site1242
Active site1244

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase
  • EC number
  • Short names
    FGAM synthase
    ; FGAMS
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase
      (FGAR amidotransferase
      ; FGAR-AT
      )

Gene names

    • Name
      purL
    • ORF names
      J690_1451

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 742879
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex

Accessions

  • Primary accession
    A0A013T7A4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain38-144Phosphoribosylformylglycinamidine synthase N-terminal
Domain165-214Phosphoribosylformylglycinamidine synthase linker
Region303-327Disordered
Domain424-582PurM-like C-terminal
Domain641-800FGAR-AT PurM-N-like
Domain851-907PurM-like C-terminal

Sequence similarities

In the N-terminal section; belongs to the FGAMS family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,277
  • Mass (Da)
    139,460
  • Last updated
    2014-06-11 v1
  • MD5 Checksum
    161CA9D619BC5443961DD8031059D357
MFIVAGAAAHSSFKKAQLLTRLSSISSVQSFDSQWVYLFDQALNEQQHQSALQLLNDGESFELRQSASDEIQILVTPRVGTISPWSSKATDIFKNCNTPVHRLERGLLFTLKGVTEITNEVKQVLHDRMTETVFAQIEDAKALFSETAPKPLNSIDILGQGKEALVKANNEFGFALSEQEIDYLTEAFGKLGRNPNDIELMMFAQANSEHCRHKIFGSEWTIDGEKQPLSLFQMIKNTYKESPTDVLSAYKDNASVIVGYDTMRFYPKADENGHFVYKYKSQAAHILMKVETHNHPTAISPFAGAATGSGGEIRDEGATGRGGKPKAGLTGFTVSNLNIPSFEQPWEENYGKPSRMASPLQIMIEGPLGGAAFNNEFGRPALNGYFRTFEQNVNGEVKGFHKPIMIAGGYGNIRPDHVEKDAIQPGDLLIVLGGPAMLIGLGGGAASSVDSGTMGESLDFASVQRENPEMERRCQEVIDTCWRLEDFNPIVSVHDVGAGGLSNAMPELVNDHELGAVLNLRKIPSLEPGMSPMEIWSNEAQERYVLAIRPESLEQFESICARERCPFAVLGEATEARHLTVEDPLFQNNAVDIPMQVMLGGTPRMQRSYETIERKGNEFDASKVDLKDAIFRVLKNPTVASKSFLITIGDRSITGMVARDQMVGRWQIPVADAAVTTTSLQGFTGEAMAMGERPPVALLNPAASARLAVAEAITNIACANIEQISDIKLSANWMAAAGQKGEDQALFEGVKAIGMEMCPALGIAIPVGKDSLSMRTTWNENGEDKAVTSPMTGVITAFAPVTDVRKTLTPELKNLEDSVLVRIDLSKGQFRLGGSILAQVYKAIGSITPDVDSFDDFKAFFALIQDWNNRGLIQAYHDIGDGGLLATVAEMMFAARLGVALEDQTPASLFAEEIGAVLQIKATDWDALQAEVAASSLKDAIAVVGRINNTDQLSVNGLTLERAELQQAWSEVSHQIQRLRDNVETADQEFALIADKSHQGLIAKPTFDLNEPIEAPFINTRRPNMAILREQGVNGHIEMAAAFDKVGFNTVDVHMSDLLAGRVSLSDFEGLVTCGGFSYGDVMGAGGGWAKSVLFNAKLRDQFEQFFHREDTFSLGICNGCQMLSQLSPLIPGAEHWPRFHRNMSEVFEARSVNVRVEKSVSVLLNGMEGSILPIAVAHGEGRAVASEADIAGLNAANQVALRYVDSHGNPTQHYPLNPNGSPEAITGVTSKDGRATIMMPHPERTFRAIQHSWSPEEWTEDGAWLRMFRNARKFIG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JFYC01000004
EMBL· GenBank· DDBJ
EXS29091.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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