A0A013T7A4 · A0A013T7A4_9GAMM
- ProteinPhosphoribosylformylglycinamidine synthase
- GenepurL
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1277 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
Catalytic activity
- N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N1-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H+
Pathway
Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 304-315 | ATP (UniProtKB | ChEBI) | |||
Binding site | 671 | ATP (UniProtKB | ChEBI) | |||
Binding site | 672 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 711 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 715 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 878 | Mg2+ (UniProtKB | ChEBI) | |||
Active site | 1118 | Nucleophile | |||
Active site | 1242 | ||||
Active site | 1244 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoribosylformylglycinamidine synthase activity | |
Biological Process | 'de novo' IMP biosynthetic process | |
Biological Process | glutamine metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoribosylformylglycinamidine synthase
- EC number
- Short namesFGAM synthase ; FGAMS
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex
Accessions
- Primary accessionA0A013T7A4
Proteomes
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 38-144 | Phosphoribosylformylglycinamidine synthase N-terminal | |||
Domain | 165-214 | Phosphoribosylformylglycinamidine synthase linker | |||
Region | 303-327 | Disordered | |||
Domain | 424-582 | PurM-like C-terminal | |||
Domain | 641-800 | FGAR-AT PurM-N-like | |||
Domain | 851-907 | PurM-like C-terminal | |||
Sequence similarities
In the N-terminal section; belongs to the FGAMS family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,277
- Mass (Da)139,460
- Last updated2014-06-11 v1
- MD5 Checksum161CA9D619BC5443961DD8031059D357
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JFYC01000004 EMBL· GenBank· DDBJ | EXS29091.1 EMBL· GenBank· DDBJ | Genomic DNA |