A0A013SZ02 · A0A013SZ02_9GAMM
- ProteinRNA 3'-terminal phosphate cyclase
- GenertcA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids348 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Catalytic activity
- a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 110 | ATP (UniProtKB | ChEBI) | |||
Binding site | 291-295 | ATP (UniProtKB | ChEBI) | |||
Active site | 316 | Tele-AMP-histidine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | RNA-3'-phosphate cyclase activity | |
Biological Process | RNA processing |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRNA 3'-terminal phosphate cyclase
- EC number
- Short namesRNA cyclase ; RNA-3'-phosphate cyclase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex
Accessions
- Primary accessionA0A013SZ02
Proteomes
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length348
- Mass (Da)38,286
- Last updated2014-06-11 v1
- MD5 Checksum0571D37083B4B21C0EBD46DA9008B0DA
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JFYD01000001 EMBL· GenBank· DDBJ | EXS36382.1 EMBL· GenBank· DDBJ | Genomic DNA |