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A0A013S522 · A0A013S522_9GAMM

  • Protein
    Hydroxyacylglutathione hydrolase
  • Gene
    gloB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site58Zn2+ 1 (UniProtKB | ChEBI)
Binding site60Zn2+ 1 (UniProtKB | ChEBI)
Binding site62Zn2+ 2 (UniProtKB | ChEBI)
Binding site63Zn2+ 2 (UniProtKB | ChEBI)
Binding site116Zn2+ 1 (UniProtKB | ChEBI)
Binding site135Zn2+ 1 (UniProtKB | ChEBI)
Binding site135Zn2+ 2 (UniProtKB | ChEBI)
Binding site173Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionhydroxyacylglutathione hydrolase activity
Molecular Functionmetal ion binding
Biological Processmethylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hydroxyacylglutathione hydrolase
  • EC number
  • Alternative names
    • Glyoxalase II
      (Glx II
      )

Gene names

    • Name
      gloB
    • ORF names
      J690_1056

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 742879
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex

Accessions

  • Primary accession
    A0A013S522

Proteomes

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-173Metallo-beta-lactamase

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    243
  • Mass (Da)
    27,674
  • Last updated
    2014-06-11 v1
  • MD5 Checksum
    9C0BD52BF8BD8A5211E9BB4099FF1568
MRYRIHFIDVQNALQNYIWILEDTETQEAVAVDPTEADLVTQFCQNHQLTLKQIWLTHWHKDHIGGVADLTTAQNITVYGPRDELTKIPGITHPLQHDDHLKFNDLKVEIIATPGHTLGHIVYFIEELEAVFCGDTLFAMGCGRLFEGTAEQMYHSLSRLAALPTQTKVYCTHEYTLSNAEFALTVEPHNHALSERAEEVRELRKKGSITLPSTIELELATNPFLRAESAEDFAHLRALKDNF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JFYC01000003
EMBL· GenBank· DDBJ
EXS29479.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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