A0A011QP26 · A0A011QP26_9PROT

Function

function

Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site59-63(6S)-NADPHX (UniProtKB | ChEBI)
Binding site60K+ (UniProtKB | ChEBI)
Binding site122K+ (UniProtKB | ChEBI)
Binding site126-132(6S)-NADPHX (UniProtKB | ChEBI)
Binding site159(6S)-NADPHX (UniProtKB | ChEBI)
Binding site162K+ (UniProtKB | ChEBI)
Binding site259(6S)-NADPHX (UniProtKB | ChEBI)
Binding site315(6S)-NADPHX (UniProtKB | ChEBI)
Binding site371(6S)-NADPHX (UniProtKB | ChEBI)
Binding site408-412AMP (UniProtKB | ChEBI)
Binding site437AMP (UniProtKB | ChEBI)
Binding site438(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Biological Processnicotinamide nucleotide metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional NAD(P)H-hydrate repair enzyme
  • Alternative names
    • Nicotinamide nucleotide repair protein

Including 2 domains:

  • Recommended name
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ADP-dependent NAD(P)HX dehydratase
  • Recommended name
    NAD(P)H-hydrate epimerase
  • EC number

Gene names

    • Name
      nnr
    • Synonyms
      nnrD
      , nnrE
    • ORF names
      AW10_01772

Organism names

Accessions

  • Primary accession
    A0A011QP26

Proteomes

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-216YjeF N-terminal
Domain224-498YjeF C-terminal

Sequence similarities

Belongs to the NnrD/CARKD family.
Belongs to the NnrE/AIBP family.
In the C-terminal section; belongs to the NnrD/CARKD family.
In the N-terminal section; belongs to the NnrE/AIBP family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    503
  • Mass (Da)
    51,909
  • Last updated
    2014-06-11 v1
  • Checksum
    CED358A4662E940A
MTTPIRSEPLYRAADLRRIEAAAAAQPLMQRAGEAAADLAISLSRLEGGAVLILAGPGNNGGDAFVAARHLRQRGFAVSVVFVGELSRLPKDAAAAYQDFDEDGGSTLESIPSGSRWSLIIDGLFGIGLQRAVSGRFAELVTAANALALRHHCPLLALDCPSGLDADTGRRCGETIRASHTITFIAGKPGLFTGDGPEYCGSITHAALDLHAERLTPPSARTIGSDLFAACLRPRAKNTHKGSFGNAGVLGGASSMVGAVFLAGRAALRLGSGRVYLGLLDAQAPSFDPLQPELMLRRPEVLLTTTLSALACGPGMGGSDEARELLLRACALDLPLLLDADALNLLASDAPLQEALSGRAQRGVATLLTPHPTEAARMLAGDTAQVQADRAGAALELARRYGVVVVLKGCGTIVATPDGRWFVNTTGHPALATAGTGDVLSGMIVALLAQGWPALEASLAGVHLHGAAAEERVASGYGPVGLTAGEIIDSARLCLNHWIAHGR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JEMX01000030
EMBL· GenBank· DDBJ
EXI80629.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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