Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A011PKT1 · A0A011PKT1_9PROT

Function

function

Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.

Features

Showing features for binding site.

138350100150200250300350
TypeIDPosition(s)Description
Binding site163K+ (UniProtKB | ChEBI)
Binding site163-168GTP (UniProtKB | ChEBI)
Binding site167Mg2+ (UniProtKB | ChEBI)
Binding site182K+ (UniProtKB | ChEBI)
Binding site182-188GTP (UniProtKB | ChEBI)
Binding site184K+ (UniProtKB | ChEBI)
Binding site187K+ (UniProtKB | ChEBI)
Binding site188Mg2+ (UniProtKB | ChEBI)
Binding site207-210GTP (UniProtKB | ChEBI)
Binding site291-293GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmetal ion binding
Biological ProcesstRNA methylation
Biological ProcesstRNA wobble uridine modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA modification GTPase MnmE
  • EC number

Gene names

    • Name
      mnmE
    • Synonyms
      trmE
    • ORF names
      AW10_03772

Organism names

Accessions

  • Primary accession
    A0A011PKT1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, coiled coil.

Type
IDPosition(s)Description
Domain153-310TrmE-type G
Coiled coil321-355

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    383
  • Mass (Da)
    41,412
  • Last updated
    2014-06-11 v1
  • MD5 Checksum
    A613F487B3A7116F7B7A405EB2D9C95C
MLLHFPGPNSFTGEDVLELHGHGGPVVMKMLLARCLELGASLAEPGEFTRRAYLNGKLDLAQAEAVIDLIDAATAAAARSAVRSLQGEFSREVAALLEQLVELRALVEATLDFPEEEVDFLEASDAFGRLDRLRQRLATVFDRAQQGRLLQGGLHVVLAGQPNVGKSSLLNRLAGDELAIVTALPGTTRDVVRSTLQLEGIPLHVIDTAGLRETNDPIEQIGIERSWREIERADVVVLLVDARSGVGQADRAIVARLPGHLARVTVHNKIDLAGRGAASMNDADGVAIALSARSGEGIELLRQALLQIAGWHPAEDVFIARERHLSALSETRQRIEQAQAQLPRLELFAEELRLAQLALATITGEFSADDLLGEIFGRFCIGK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JEMX01000098
EMBL· GenBank· DDBJ
EXI77420.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help